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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 1997 Volume 10 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1997 Volume 10 Issue 1

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Article

The role of fibroblast growth factor (FGF) in neoplasms induced by MoMuSV-349

  • Authors:
    • G Stoica
    • R Hoffman
    • J Hawker
    • M Lawrence
    • K Kelly
    • C Meininger

  • View Affiliations / Copyright

    Affiliations: TEXAS A&M UNIV,COLL MED,DEPT MED PHYSIOL,COLLEGE STN,TX 77843. TEXAS A&M UNIV,COLL MED,DIV CARDIOL,COLLEGE STN,TX 77843. OKLAHOMA STATE UNIV,COLL VET MED,DEPT VET PATHOL,STILLWATER,OK 74078.
  • Pages: 205-211
    |
    Published online on: January 1, 1997
       https://doi.org/10.3892/ijo.10.1.205
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Abstract

Previous results from our laboratory have demonstrated that intraperitoneal inoculation of newborn BALB/c mice with MoMuSV-349 virus induced multiorgan disseminated angiomatous tumors. Changes in histological pattern, from sarcomatous to angiosarcomatous, stimulated our interest in investigating the possible role of angiogenic growth factors released by the spindled (sarcomatous) cells in angiosarcoma development in this model. Cell lines were obtained from various tumors and assayed for production of acidic (a) and basic (b) fibroblast growth factors (FGFs). All tumor cell lines released detectable amounts of growth factor(s) into the cultured media that induced proliferation of endothelial cells and mitogenesis of mouse fibroblasts. This growth factor(s) bound to heparin Sepharose (HS) beads and its effects on cell proliferation were partially blocked by a neutralizing bFGF antibody. Proteins released by tumor cells into the conditioned medium were detected by bFGF antibodies on Western blots. In addition, proteins that reacted with both bFGF and aFGF antibodies were detected in various conditioned media by ELISA. This protein(s) from the FGF family detected in the conditioned media from various tumor cell lines might be responsible for the angiomatous proliferation observed in the late (angiosarcomatous) stage of MoMuSV-induced tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Stoica G, Hoffman R, Hawker J, Lawrence M, Kelly K and Meininger C: The role of fibroblast growth factor (FGF) in neoplasms induced by MoMuSV-349. Int J Oncol 10: 205-211, 1997.
APA
Stoica, G., Hoffman, R., Hawker, J., Lawrence, M., Kelly, K., & Meininger, C. (1997). The role of fibroblast growth factor (FGF) in neoplasms induced by MoMuSV-349. International Journal of Oncology, 10, 205-211. https://doi.org/10.3892/ijo.10.1.205
MLA
Stoica, G., Hoffman, R., Hawker, J., Lawrence, M., Kelly, K., Meininger, C."The role of fibroblast growth factor (FGF) in neoplasms induced by MoMuSV-349". International Journal of Oncology 10.1 (1997): 205-211.
Chicago
Stoica, G., Hoffman, R., Hawker, J., Lawrence, M., Kelly, K., Meininger, C."The role of fibroblast growth factor (FGF) in neoplasms induced by MoMuSV-349". International Journal of Oncology 10, no. 1 (1997): 205-211. https://doi.org/10.3892/ijo.10.1.205
Copy and paste a formatted citation
x
Spandidos Publications style
Stoica G, Hoffman R, Hawker J, Lawrence M, Kelly K and Meininger C: The role of fibroblast growth factor (FGF) in neoplasms induced by MoMuSV-349. Int J Oncol 10: 205-211, 1997.
APA
Stoica, G., Hoffman, R., Hawker, J., Lawrence, M., Kelly, K., & Meininger, C. (1997). The role of fibroblast growth factor (FGF) in neoplasms induced by MoMuSV-349. International Journal of Oncology, 10, 205-211. https://doi.org/10.3892/ijo.10.1.205
MLA
Stoica, G., Hoffman, R., Hawker, J., Lawrence, M., Kelly, K., Meininger, C."The role of fibroblast growth factor (FGF) in neoplasms induced by MoMuSV-349". International Journal of Oncology 10.1 (1997): 205-211.
Chicago
Stoica, G., Hoffman, R., Hawker, J., Lawrence, M., Kelly, K., Meininger, C."The role of fibroblast growth factor (FGF) in neoplasms induced by MoMuSV-349". International Journal of Oncology 10, no. 1 (1997): 205-211. https://doi.org/10.3892/ijo.10.1.205
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