Genetically modified tumour vaccines

Rossner,P; Bubenik,J; Indrova,M; Sobota,V; Vondrys,P; Zeuthen,J; Jandlova,T; Takac,M

doi:10.3892/ijo.10.1.77

January 1997 Volume 10 Issue 1

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International Journal of Molecular Medicine

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January 1997 Volume 10 Issue 1

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Cover Legend PDF

Article

Genetically modified tumour vaccines

Authors:
- P Rossner
- J Bubenik
- M Indrova
- V Sobota
- P Vondrys
- J Zeuthen
- T Jandlova
- M Takac
View Affiliations / Copyright

Affiliations: ACAD SCI CZECH REPUBL,INST MOL GENET,CR-16637 PRAGUE 6,CZECH REPUBLIC. DANISH CANC SOC,DIV CANC BIOL,DK-2100 COPENHAGEN O,DENMARK.
Pages: 77-82
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Published online on: January 1, 1997

https://doi.org/10.3892/ijo.10.1.77
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Abstract

Two genes, the gene coding for IL-2 and the gene encoding the CD80 molecule, were inserted into murine sarcoma MC12 cells. Tumorigenicity of a variety of cell clones with different expression of the inserted genes was assessed. Most of the genetically manipulated MC12 cell clones were less tumorigenic than the parental MC12 cell population. Tumorigenicity of the clones declined with increasing production of IL-2 as well as with the increasing expression of the CD80 molecule. When the tumorigenicity of the clones carrying an inserted IL-2 gene was compared with that of the clones carrying an inserted CD80 gene, it was found that the insertion of the IL-2 gene suppresses tumorigenicity more efficiently than insertion of the CD80 gene. Admixture of the IL-2-producing MC12 clones to the tumorigenic CD80(+) MC12 cell doses could completely inhibit the tumorigenicity of the CD80(+) cells. Insertion of the CD80 gene into sarcoma cells substantially enhanced the adhesive interaction between the MC12 sarcoma and syngeneic T lymphocytes.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Genetically modified tumour vaccines

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Abstract

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