Non-coexpression of collagenase and transin in malignant epithelial cells
- M Paine
- J Gibbins
- R Kefford
Affiliations: UNIV SYDNEY,DEPT PATHOL,SYDNEY,NSW 2006,AUSTRALIA. UNIV SYDNEY,WESTMEAD HOSP,DEPT MED ONCOL,WESTMEAD,NSW 2145,AUSTRALIA.
- Published online on: March 1, 1997 https://doi.org/10.3892/ijo.10.3.615
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Increased synthesis and secretion of the matrix metalloproteinase has been associated with the acquisition of the invasive properties of malignant cells. In a rat malignant anaplastic cell line (T952/F7) sporadic expression of mRNA for collagenase-3 against a background of high transin-l mRNA has been shown. Sporadic induction of either metalloproteinase was not found in the benign precursor cells (A5P/B10) of T952/F7 cells, but a coordinate mRNA induction profile for these two genes could be induced by the addition of 12-O-tetradecanoylphorbol-13-acetate. In a different uncloned neoplastic epithelial cell line (BCl) fluctuations in the levels of collagenase and transin appeared coordinately, but coordinate expression was not a feature in cloned lines derived from BCl. The loss of coordinate regulation of the two matrix metalloproteinases may relate to the variability in metastatic potential seen in clonal cell lines.