Expression of matrix metalloproteinases 1 and 2 genes in a possible association with metastatic abilities of human pancreatic cancer cells
- S Jimi
- T Shono
- M Ono
- M Kuwano
- M Tanaka
- C LopezOtin
- A Kono
Affiliations: KYUSHU UNIV,SCH MED,DEPT SURG 1,HIGASHI KU,FUKUOKA 81282,JAPAN. UNIV OVIEDO,FAC MED,DEPT BIOQUIM & BIOL MOL,E-33006 OVIEDO,SPAIN. KYUSHU NATL CANC CTR,CHEMOTHERAPY DIV,RES INST,FUKUOKA 816,JAPAN.
- Published online on: March 1, 1997 https://doi.org/10.3892/ijo.10.3.623
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We determined if any extracellular matrix degradative proteases were possibly associated with metastatic potentials of human pancreatic cancer cells. Liver metastatic abilities of six human pancreatic cancer cell lines were examined in nude mice, and divided into two high (2 lines) and low (4 lines) metastatic cell lines. Of six cell lines, matrix metalloproteinases-1 (MMP-1) was overexpressed in two high metastatic cell lines: and MMP-2 was overexpressed in one high metastatic cell line. Of the four low metastatic lines, two cell lines had relatively higher mRNA levels of tissue inhibitors of metalloproteinases-3 (TIMP-3). MMP activities due to MMP-1 and MMP-2 might be positively associated with liver metastasis of pancreatic cancer cells. Moreover, expression of TIMP-3 might be partly involved in the low metastatic potentials of pancreatic cancer.