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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 1997 Volume 10 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 1997 Volume 10 Issue 4

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Article

In vivo gene therapy of murine melanoma mediated by recombinant vaccinia virus encoding human IL-2 gene

  • Authors:
    • T Wan
    • X Cao
    • D Ju
    • B Aces

  • View Affiliations / Copyright

    Affiliations: MIL MED COLL 2,DEPT IMMUNOL,SHANGHAI 200433,PEOPLES R CHINA. TRANSGENE SA,DEPT IMMUNOL,F-67082 STRASBOURG,FRANCE.
  • Pages: 703-708
    |
    Published online on: April 1, 1997
       https://doi.org/10.3892/ijo.10.4.703
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Abstract

Direct gene transfer into somatic tissue iii vivo is a developing technology with potential application for cancer gene therapy. In this study, recombinant vaccinia virus encoding human IL-2 gene (rVV-IL-2) was used as a candidate vector in mediating iii vivo gene therapy. After rVV-IL-2 was expanded in VERO cells for 72 h, high titer (10(8)-10(10) PFU/ml) rVV-IL-2 were harvested. When 10(6) murine melanoma cells (F16-F10) were infected with rVV-IL-2, about 200 U/ml IL-2 activity was detected in the supernatants at 8 h, and the up-regulation of ICAM-1 and MHC-I expressions on the melanoma cells were observed. The treatment of murine melanoma model by local injection of rVV-IL-2 into the tumor site showed that rVV-IL-2 transfection significantly inhibited the tumor growth and prolonged the survival time of tumor-bearing mice. The splenocytes from rVV-IL-2 treated mice showed higher cytotoxicities of NK, LAK and CTL in comparison with those from the controls. These results suggest that in vivo transfection mediated by rVV-IL-2 has potential effectiveness in enhancing host immunity and would be a useful approach to cancer gene therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Wan T, Cao X, Ju D and Aces B: In vivo gene therapy of murine melanoma mediated by recombinant vaccinia virus encoding human IL-2 gene. Int J Oncol 10: 703-708, 1997.
APA
Wan, T., Cao, X., Ju, D., & Aces, B. (1997). In vivo gene therapy of murine melanoma mediated by recombinant vaccinia virus encoding human IL-2 gene. International Journal of Oncology, 10, 703-708. https://doi.org/10.3892/ijo.10.4.703
MLA
Wan, T., Cao, X., Ju, D., Aces, B."In vivo gene therapy of murine melanoma mediated by recombinant vaccinia virus encoding human IL-2 gene". International Journal of Oncology 10.4 (1997): 703-708.
Chicago
Wan, T., Cao, X., Ju, D., Aces, B."In vivo gene therapy of murine melanoma mediated by recombinant vaccinia virus encoding human IL-2 gene". International Journal of Oncology 10, no. 4 (1997): 703-708. https://doi.org/10.3892/ijo.10.4.703
Copy and paste a formatted citation
x
Spandidos Publications style
Wan T, Cao X, Ju D and Aces B: In vivo gene therapy of murine melanoma mediated by recombinant vaccinia virus encoding human IL-2 gene. Int J Oncol 10: 703-708, 1997.
APA
Wan, T., Cao, X., Ju, D., & Aces, B. (1997). In vivo gene therapy of murine melanoma mediated by recombinant vaccinia virus encoding human IL-2 gene. International Journal of Oncology, 10, 703-708. https://doi.org/10.3892/ijo.10.4.703
MLA
Wan, T., Cao, X., Ju, D., Aces, B."In vivo gene therapy of murine melanoma mediated by recombinant vaccinia virus encoding human IL-2 gene". International Journal of Oncology 10.4 (1997): 703-708.
Chicago
Wan, T., Cao, X., Ju, D., Aces, B."In vivo gene therapy of murine melanoma mediated by recombinant vaccinia virus encoding human IL-2 gene". International Journal of Oncology 10, no. 4 (1997): 703-708. https://doi.org/10.3892/ijo.10.4.703
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