Identification of a gp100 epitope recognized by HLA-A3 restricted melanoma infiltrating lymphocytes

  • Authors:
    • A MoreauAubry
    • J Fonteneau
    • N Labarriere
    • F Jotereau
    • E Houssaint
    • R Breathnach
  • View Affiliations

  • Published online on: April 1, 1997     https://doi.org/10.3892/ijo.10.4.841
  • Pages: 841-846
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Abstract

The large majority of known melanoma-associated antigenic peptides presented by MHC class I molecules are presented by the most frequent allele, HLA-A*0201. Thus although a significant percentage of Caucasians express HLA-A3, no melanoma-associated antigenic peptide presented by this allele has yet been identified. We show here that the T cell clone M45-10 isolated from tumor infiltrating lymphocytes recovered from a melanoma biopsy recognizes the gp100-derived peptide ALLAVGATK presented by HLA-A*0301. Since gp100 is expressed on most melanoma cells, our results imply that the gp100-based anti-melanoma strategies developed for individuals expressing HLA-A2 will also be applicable to those expressing HLA-AS (about one Caucasian in four). gp100 is therefore a particularly promising melanoma antigen, as different peptides derived from it can be presented by at least two different frequently encountered HLA class I molecules.

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April 1997
Volume 10 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
MoreauAubry A, Fonteneau J, Labarriere N, Jotereau F, Houssaint E and Breathnach R: Identification of a gp100 epitope recognized by HLA-A3 restricted melanoma infiltrating lymphocytes. Int J Oncol 10: 841-846, 1997
APA
MoreauAubry, A., Fonteneau, J., Labarriere, N., Jotereau, F., Houssaint, E., & Breathnach, R. (1997). Identification of a gp100 epitope recognized by HLA-A3 restricted melanoma infiltrating lymphocytes. International Journal of Oncology, 10, 841-846. https://doi.org/10.3892/ijo.10.4.841
MLA
MoreauAubry, A., Fonteneau, J., Labarriere, N., Jotereau, F., Houssaint, E., Breathnach, R."Identification of a gp100 epitope recognized by HLA-A3 restricted melanoma infiltrating lymphocytes". International Journal of Oncology 10.4 (1997): 841-846.
Chicago
MoreauAubry, A., Fonteneau, J., Labarriere, N., Jotereau, F., Houssaint, E., Breathnach, R."Identification of a gp100 epitope recognized by HLA-A3 restricted melanoma infiltrating lymphocytes". International Journal of Oncology 10, no. 4 (1997): 841-846. https://doi.org/10.3892/ijo.10.4.841