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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 1997 Volume 10 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 1997 Volume 10 Issue 5

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Article

Changes in chromosomes 1 and 6 associated with human cell immortalisation

  • Authors:
    • E Mitchell
    • A Kinsella
  • View Affiliations / Copyright

    Affiliations: UNIV LIVERPOOL, DEPT SURG, CELLULAR ONCOL GRP, LIVERPOOL L69 3GA, MERSEYSIDE, ENGLAND. CHRISTIE HOSP & HOLT RADIUM INST, PATERSON INST CANC RES, CRC, DEPT CANC GENET, MANCHESTER M20 9BX, LANCS, ENGLAND.
  • Pages: 977-981
    |
    Published online on: May 1, 1997
       https://doi.org/10.3892/ijo.10.5.977
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Abstract

A normal diploid human fibroblast cell line infected with HL60 c-myc has become immortal in vitro following continuous passage. At early passage post-infection the cells exhibited a normal diploid karyotype and in the absence of karyotypic changes grew well beyond the normal passage at which senescence occurred in the normal non-transfected parental cell line or the vector-infected control. Immortalisation of both the infected population and a subclone taken prior to karyotypic change was associated with two independent events involving chromosome 1. The subcloned population also possessed a deletion of the long arm of chromosome 6.

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Spandidos Publications style
Mitchell E and Kinsella A: Changes in chromosomes 1 and 6 associated with human cell immortalisation. Int J Oncol 10: 977-981, 1997.
APA
Mitchell, E., & Kinsella, A. (1997). Changes in chromosomes 1 and 6 associated with human cell immortalisation. International Journal of Oncology, 10, 977-981. https://doi.org/10.3892/ijo.10.5.977
MLA
Mitchell, E., Kinsella, A."Changes in chromosomes 1 and 6 associated with human cell immortalisation". International Journal of Oncology 10.5 (1997): 977-981.
Chicago
Mitchell, E., Kinsella, A."Changes in chromosomes 1 and 6 associated with human cell immortalisation". International Journal of Oncology 10, no. 5 (1997): 977-981. https://doi.org/10.3892/ijo.10.5.977
Copy and paste a formatted citation
x
Spandidos Publications style
Mitchell E and Kinsella A: Changes in chromosomes 1 and 6 associated with human cell immortalisation. Int J Oncol 10: 977-981, 1997.
APA
Mitchell, E., & Kinsella, A. (1997). Changes in chromosomes 1 and 6 associated with human cell immortalisation. International Journal of Oncology, 10, 977-981. https://doi.org/10.3892/ijo.10.5.977
MLA
Mitchell, E., Kinsella, A."Changes in chromosomes 1 and 6 associated with human cell immortalisation". International Journal of Oncology 10.5 (1997): 977-981.
Chicago
Mitchell, E., Kinsella, A."Changes in chromosomes 1 and 6 associated with human cell immortalisation". International Journal of Oncology 10, no. 5 (1997): 977-981. https://doi.org/10.3892/ijo.10.5.977
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