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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1997 Volume 10 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June 1997 Volume 10 Issue 6

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Article

Interaction between human cancer cells and cultured murine endothelial cells, and its relationship with metastatic potential

  • Authors:
    • M Sato
    • T Narita
    • N Kimura
    • T Nakashio
    • T Hashimoto
    • T Manabe
    • R Kannagi

  • View Affiliations / Copyright

    Affiliations: AICHI CANC CTR,RES INST,LAB EXPT PATHOL,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN. NAGOYA UNIV,SCH MED,DEPT SURG 2,SHOWA KU,NAGOYA,AICHI 466,JAPAN.
  • Pages: 1173-1178
    |
    Published online on: June 1, 1997
       https://doi.org/10.3892/ijo.10.6.1173
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Abstract

The hematogenous metastasis of cancer consists of a multistep process. It is surmised that a number of interactions between cancer and endothelial cells occur, with cell adhesion molecules playing certain roles in this process. The authors conducted an investigation on the interaction between human cancer cells and cultured murine endothelial cells (F-2 cells) in vitro, and on its relationship with the metastatic activity of cancer cells in vivo. A correlation was found between the degree of expression of carbohydrate antigens on the cell surface and adhesion of cancer cells to F-2 cells. Five of 13 examined cell lines showed liver metastasis after inoculation to the spleen of nude mice. These cell lines showed not only a strong binding activity to F-2 cells but implantation in F-2 cells in vitro was also observed. These findings suggest that adhesion to, and implantation in endothelial cells are necessary for the induction of distant metastasis. Treatment with antibodies against carbohydrate antigens inhibited the formation of liver metastasis in nude mice. It is possible that strategies to interfere with the function of cell adhesion molecules may be formulated to result in the decreased distant metastasis of cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Sato M, Narita T, Kimura N, Nakashio T, Hashimoto T, Manabe T and Kannagi R: Interaction between human cancer cells and cultured murine endothelial cells, and its relationship with metastatic potential. Int J Oncol 10: 1173-1178, 1997.
APA
Sato, M., Narita, T., Kimura, N., Nakashio, T., Hashimoto, T., Manabe, T., & Kannagi, R. (1997). Interaction between human cancer cells and cultured murine endothelial cells, and its relationship with metastatic potential. International Journal of Oncology, 10, 1173-1178. https://doi.org/10.3892/ijo.10.6.1173
MLA
Sato, M., Narita, T., Kimura, N., Nakashio, T., Hashimoto, T., Manabe, T., Kannagi, R."Interaction between human cancer cells and cultured murine endothelial cells, and its relationship with metastatic potential". International Journal of Oncology 10.6 (1997): 1173-1178.
Chicago
Sato, M., Narita, T., Kimura, N., Nakashio, T., Hashimoto, T., Manabe, T., Kannagi, R."Interaction between human cancer cells and cultured murine endothelial cells, and its relationship with metastatic potential". International Journal of Oncology 10, no. 6 (1997): 1173-1178. https://doi.org/10.3892/ijo.10.6.1173
Copy and paste a formatted citation
x
Spandidos Publications style
Sato M, Narita T, Kimura N, Nakashio T, Hashimoto T, Manabe T and Kannagi R: Interaction between human cancer cells and cultured murine endothelial cells, and its relationship with metastatic potential. Int J Oncol 10: 1173-1178, 1997.
APA
Sato, M., Narita, T., Kimura, N., Nakashio, T., Hashimoto, T., Manabe, T., & Kannagi, R. (1997). Interaction between human cancer cells and cultured murine endothelial cells, and its relationship with metastatic potential. International Journal of Oncology, 10, 1173-1178. https://doi.org/10.3892/ijo.10.6.1173
MLA
Sato, M., Narita, T., Kimura, N., Nakashio, T., Hashimoto, T., Manabe, T., Kannagi, R."Interaction between human cancer cells and cultured murine endothelial cells, and its relationship with metastatic potential". International Journal of Oncology 10.6 (1997): 1173-1178.
Chicago
Sato, M., Narita, T., Kimura, N., Nakashio, T., Hashimoto, T., Manabe, T., Kannagi, R."Interaction between human cancer cells and cultured murine endothelial cells, and its relationship with metastatic potential". International Journal of Oncology 10, no. 6 (1997): 1173-1178. https://doi.org/10.3892/ijo.10.6.1173
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