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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1997 Volume 10 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June 1997 Volume 10 Issue 6

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Article

p53 gene alterations are associated with a decreased responsiveness to neoadjuvant chemotherapy in human breast cancer

  • Authors:
    • S LizardNacol
    • B Coudert
    • J Riedinger
    • P Fargeot
    • J Guerrin

  • View Affiliations / Copyright

    Affiliations: CTR GEORGES FRANCOIS LECLERC,ONCOL SERV,F-21034 DIJON,FRANCE. CTR GEORGES FRANCOIS LECLERC,MED BIOL LAB,F-21034 DIJON,FRANCE.
  • Pages: 1203-1207
    |
    Published online on: June 1, 1997
       https://doi.org/10.3892/ijo.10.6.1203
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Abstract

Recent evidence indicates that alterations of the p53 tumor suppressor gene can modulate the response of tumor cells to DNA-damaging agents and increase drug resistance. To evaluate whether p53 alterations affect response to chemotherapy in breast cancer, we examined the p53 status before and after treatment of primary tumors from 44 patients who received neoadjuvant chemotherapy. p53 status was determined by gene mutations and by mRNA expression levels. Eleven patients (25%) showed alterations in the p53 gene. Comparison of the clinical response between subgroups with or without p53 alterations revealed that p53 alterations were strongly associated to clinical resistance to chemotherapy (p<0.001).

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Copy and paste a formatted citation
Spandidos Publications style
LizardNacol S, Coudert B, Riedinger J, Fargeot P and Guerrin J: p53 gene alterations are associated with a decreased responsiveness to neoadjuvant chemotherapy in human breast cancer. Int J Oncol 10: 1203-1207, 1997.
APA
LizardNacol, S., Coudert, B., Riedinger, J., Fargeot, P., & Guerrin, J. (1997). p53 gene alterations are associated with a decreased responsiveness to neoadjuvant chemotherapy in human breast cancer. International Journal of Oncology, 10, 1203-1207. https://doi.org/10.3892/ijo.10.6.1203
MLA
LizardNacol, S., Coudert, B., Riedinger, J., Fargeot, P., Guerrin, J."p53 gene alterations are associated with a decreased responsiveness to neoadjuvant chemotherapy in human breast cancer". International Journal of Oncology 10.6 (1997): 1203-1207.
Chicago
LizardNacol, S., Coudert, B., Riedinger, J., Fargeot, P., Guerrin, J."p53 gene alterations are associated with a decreased responsiveness to neoadjuvant chemotherapy in human breast cancer". International Journal of Oncology 10, no. 6 (1997): 1203-1207. https://doi.org/10.3892/ijo.10.6.1203
Copy and paste a formatted citation
x
Spandidos Publications style
LizardNacol S, Coudert B, Riedinger J, Fargeot P and Guerrin J: p53 gene alterations are associated with a decreased responsiveness to neoadjuvant chemotherapy in human breast cancer. Int J Oncol 10: 1203-1207, 1997.
APA
LizardNacol, S., Coudert, B., Riedinger, J., Fargeot, P., & Guerrin, J. (1997). p53 gene alterations are associated with a decreased responsiveness to neoadjuvant chemotherapy in human breast cancer. International Journal of Oncology, 10, 1203-1207. https://doi.org/10.3892/ijo.10.6.1203
MLA
LizardNacol, S., Coudert, B., Riedinger, J., Fargeot, P., Guerrin, J."p53 gene alterations are associated with a decreased responsiveness to neoadjuvant chemotherapy in human breast cancer". International Journal of Oncology 10.6 (1997): 1203-1207.
Chicago
LizardNacol, S., Coudert, B., Riedinger, J., Fargeot, P., Guerrin, J."p53 gene alterations are associated with a decreased responsiveness to neoadjuvant chemotherapy in human breast cancer". International Journal of Oncology 10, no. 6 (1997): 1203-1207. https://doi.org/10.3892/ijo.10.6.1203
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