Induction of cdk2 after gamma-ray irradiation is dependent on p53 status
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- Published online on: June 1, 1997 https://doi.org/10.3892/ijo.10.6.1257
- Pages: 1257-1260
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Abstract
We show that expression of cdk2 induced after gamma-ray irradiation is dependent on the p53 status in two human glioblastoma cell lines, one bearing the wild-type p53 gene and the other the mutant gene. This result indicates that wtp53 induces the expression of not only WAF1 but also cdk2. Our results suggest that p53-dependent WAF1 induction would act to prevent gene amplification and mutation in cells which sustain DNA damage in G(1) phase and p53-dependent cdk2 induction might act to prevent aneuploidy through E2F-1-DP-1 inactivation in cells which sustain DNA damage in G(2) phase.
