Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity

  • Authors:
    • R Nakashio
    • M Kitamoto
    • T Nakanishi
    • H Tahara
    • T Ide
    • T Asahara
    • G Kajiyama
  • View Affiliations

  • Published online on: July 1, 1997     https://doi.org/10.3892/ijo.11.1.139
  • Pages: 139-143
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Abstract

Length of terminal restriction fragments (TRFs) was examined in 34 samples from hepatocellular carcinoma (HCC) patients. TRF length alterations (reduction or elongation) were found in 18 of 34 (53%) HCC nodules (13 cases reduced, 5 cases elongated). The incidence of TRF alteration was significantly higher in HCC exceeding 3 cm in diameter, moderately- or poorly-differentiated in histology, or with microscopic aggressive lesions (P<0.05). The survival rates were significantly higher in patients without alterations in TRFs (P<0.05). Specifically, all 5 cases with elongated TRFs recurred within 1 year after resection and had a poor prognosis. In contrast, the presence of telomerase activity was not associated with alterations in TRF length. The incidence of TRF length alterations increased with HCC tumor progression.

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July 1997
Volume 11 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Nakashio R, Kitamoto M, Nakanishi T, Tahara H, Ide T, Asahara T and Kajiyama G: Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity. Int J Oncol 11: 139-143, 1997
APA
Nakashio, R., Kitamoto, M., Nakanishi, T., Tahara, H., Ide, T., Asahara, T., & Kajiyama, G. (1997). Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity. International Journal of Oncology, 11, 139-143. https://doi.org/10.3892/ijo.11.1.139
MLA
Nakashio, R., Kitamoto, M., Nakanishi, T., Tahara, H., Ide, T., Asahara, T., Kajiyama, G."Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity". International Journal of Oncology 11.1 (1997): 139-143.
Chicago
Nakashio, R., Kitamoto, M., Nakanishi, T., Tahara, H., Ide, T., Asahara, T., Kajiyama, G."Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity". International Journal of Oncology 11, no. 1 (1997): 139-143. https://doi.org/10.3892/ijo.11.1.139