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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1997 Volume 11 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1997 Volume 11 Issue 3

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Article

Mutational analysis of the hMSH2 gene in a wide variety of tumors

  • Authors:
    • Y Hatta
    • M Wada
    • S Takeuchi
    • T Tasaka
    • E Lee
    • Y Lee
    • B Kim
    • Y Bang
    • S Lee
    • Y Yamada
    • M Tomonaga
    • S Wilczynski
    • J Said
    • H Koeffler

  • View Affiliations / Copyright

    Affiliations: HAN YANG UNIV HOSP,DEPT INTERNAL MED,DIV HEMATOL ONCOL,SEOUL,SOUTH KOREA. SEOUL NATL UNIV HOSP,SEOUL 110744,SOUTH KOREA. CEDARS SINAI MED CTR,LOS ANGELES,CA 90048. NAGASAKI UNIV,SCH MED,DEPT LAB MED,NAGASAKI 852,JAPAN. NAGASAKI UNIV,SCH MED,DEPT HEMATOL,INST ATOM DIS,NAGASAKI 852,JAPAN. CITY HOPE NATL MED CTR,DEPT PATHOL ANAT,DAURTE,CA. UNIV CALIF LOS ANGELES,CTR HLTH SCI,DEPT PATHOL,SCH MED,LOS ANGELES,CA 90024.
  • Pages: 465-469
    |
    Published online on: September 1, 1997
       https://doi.org/10.3892/ijo.11.3.465
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Abstract

The hMSH2 gene participates in DNA mismatch repair and its mutation can result in genetic instability of the human genome which is an important feature of tumorigenesis. In this study, genetic alterations of the hMSH2 gene were examined in 43 ovarian, 36 non-small cell lung (NSCL), 31 poorly differentiated gastric, 15 endometrial, and 11 colon cancers, nine gastric cancer cell lines, 41 adult T-cell leukemias (ATLs), two ATL cell lines, and 37 non-Hodgkin's lymphomas (NHLs), using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique. Microsatellite instability (MSI) was also investigated for ovarian, NSCL, and colon cancers. The incidence of MSI was 1/36 (3%) for NSCL, 2/23 (9%) for ovarian, and 1/11 (9%) for colon cancers. Missense base changes of the hMSH2 gene were identified in two gastric cancer patients (ATG to ATA resulting in Met changing to Ile at codon 688 in exon 13 and ACA to GCA resulting in Thr changing to Ala at codon 803 in exon 14). These mutations were found in samples with no MSI. One ovarian and one gastric cancer, and six ATL samples showed two types of polymorphisms of hMSH2 (CTT to TTT resulting in Leu changing to Phe at codon 390 in exon 7 and CAG to AAG resulting in Gin to Arg at codon 419 in exon 7). Our data suggest that MSI and hMSH2 mutations are uncommon in sporadic tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Hatta Y, Wada M, Takeuchi S, Tasaka T, Lee E, Lee Y, Kim B, Bang Y, Lee S, Yamada Y, Yamada Y, et al: Mutational analysis of the hMSH2 gene in a wide variety of tumors. Int J Oncol 11: 465-469, 1997.
APA
Hatta, Y., Wada, M., Takeuchi, S., Tasaka, T., Lee, E., Lee, Y. ... Koeffler, H. (1997). Mutational analysis of the hMSH2 gene in a wide variety of tumors. International Journal of Oncology, 11, 465-469. https://doi.org/10.3892/ijo.11.3.465
MLA
Hatta, Y., Wada, M., Takeuchi, S., Tasaka, T., Lee, E., Lee, Y., Kim, B., Bang, Y., Lee, S., Yamada, Y., Tomonaga, M., Wilczynski, S., Said, J., Koeffler, H."Mutational analysis of the hMSH2 gene in a wide variety of tumors". International Journal of Oncology 11.3 (1997): 465-469.
Chicago
Hatta, Y., Wada, M., Takeuchi, S., Tasaka, T., Lee, E., Lee, Y., Kim, B., Bang, Y., Lee, S., Yamada, Y., Tomonaga, M., Wilczynski, S., Said, J., Koeffler, H."Mutational analysis of the hMSH2 gene in a wide variety of tumors". International Journal of Oncology 11, no. 3 (1997): 465-469. https://doi.org/10.3892/ijo.11.3.465
Copy and paste a formatted citation
x
Spandidos Publications style
Hatta Y, Wada M, Takeuchi S, Tasaka T, Lee E, Lee Y, Kim B, Bang Y, Lee S, Yamada Y, Yamada Y, et al: Mutational analysis of the hMSH2 gene in a wide variety of tumors. Int J Oncol 11: 465-469, 1997.
APA
Hatta, Y., Wada, M., Takeuchi, S., Tasaka, T., Lee, E., Lee, Y. ... Koeffler, H. (1997). Mutational analysis of the hMSH2 gene in a wide variety of tumors. International Journal of Oncology, 11, 465-469. https://doi.org/10.3892/ijo.11.3.465
MLA
Hatta, Y., Wada, M., Takeuchi, S., Tasaka, T., Lee, E., Lee, Y., Kim, B., Bang, Y., Lee, S., Yamada, Y., Tomonaga, M., Wilczynski, S., Said, J., Koeffler, H."Mutational analysis of the hMSH2 gene in a wide variety of tumors". International Journal of Oncology 11.3 (1997): 465-469.
Chicago
Hatta, Y., Wada, M., Takeuchi, S., Tasaka, T., Lee, E., Lee, Y., Kim, B., Bang, Y., Lee, S., Yamada, Y., Tomonaga, M., Wilczynski, S., Said, J., Koeffler, H."Mutational analysis of the hMSH2 gene in a wide variety of tumors". International Journal of Oncology 11, no. 3 (1997): 465-469. https://doi.org/10.3892/ijo.11.3.465
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