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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1997 Volume 11 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1997 Volume 11 Issue 3

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Article

Loss of DNA mismatch repair due to knockout of MSH2 or PMS2 results in resistance to cisplatin and carboplatin

  • Authors:
    • D Fink
    • S Nebel
    • S Aebi
    • A Nehme
    • S Howell

  • View Affiliations / Copyright

    Affiliations: UNIV CALIF SAN DIEGO,CTR CANC,LA JOLLA,CA 92093.
  • Pages: 539-542
    |
    Published online on: September 1, 1997
       https://doi.org/10.3892/ijo.11.3.539
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Abstract

Loss of DNA mismatch repair is a common finding in hereditary nonpolyposis colon cancer as well as in many types of sporadic human tumors. The effect of loss of DNA mismatch repair activity on sensitivity to cisplatin and carboplatin was tested using MSH2 and PMS2 knockout cell lines. The knockout dMsh2 embryonic stem cell line was 2.1-fold more resistant to cisplatin and 1.7-fold more resistant to carboplatin when compared to the isogenic wild-type wt-2 cell line. Likewise, the PMS2(-/-) mouse fibroblasts were 1.9-fold more resistant to cisplatin and 1.5-fold more resistant to carboplatin when compared to the isogenic PMS2(+/+) fibroblasts. These findings demonstrate that loss of mismatch repair due to knockout of either MSH2 or PMS2 results in low-level resistance to cisplatin and carboplatin, drugs that form the same types of adducts in DNA. These data validate results previously obtained using non-isogenic mismatch repair-proficient and -deficient cell lines, and indicate that simple recognition of the cisplatin adduct by the MSH2/MSH6 heterodimer is not sufficient for full detector function, but that PMS2 is also required for the pro-apoptotic signal to be generated from this detector.

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Copy and paste a formatted citation
Spandidos Publications style
Fink D, Nebel S, Aebi S, Nehme A and Howell S: Loss of DNA mismatch repair due to knockout of MSH2 or PMS2 results in resistance to cisplatin and carboplatin. Int J Oncol 11: 539-542, 1997.
APA
Fink, D., Nebel, S., Aebi, S., Nehme, A., & Howell, S. (1997). Loss of DNA mismatch repair due to knockout of MSH2 or PMS2 results in resistance to cisplatin and carboplatin. International Journal of Oncology, 11, 539-542. https://doi.org/10.3892/ijo.11.3.539
MLA
Fink, D., Nebel, S., Aebi, S., Nehme, A., Howell, S."Loss of DNA mismatch repair due to knockout of MSH2 or PMS2 results in resistance to cisplatin and carboplatin". International Journal of Oncology 11.3 (1997): 539-542.
Chicago
Fink, D., Nebel, S., Aebi, S., Nehme, A., Howell, S."Loss of DNA mismatch repair due to knockout of MSH2 or PMS2 results in resistance to cisplatin and carboplatin". International Journal of Oncology 11, no. 3 (1997): 539-542. https://doi.org/10.3892/ijo.11.3.539
Copy and paste a formatted citation
x
Spandidos Publications style
Fink D, Nebel S, Aebi S, Nehme A and Howell S: Loss of DNA mismatch repair due to knockout of MSH2 or PMS2 results in resistance to cisplatin and carboplatin. Int J Oncol 11: 539-542, 1997.
APA
Fink, D., Nebel, S., Aebi, S., Nehme, A., & Howell, S. (1997). Loss of DNA mismatch repair due to knockout of MSH2 or PMS2 results in resistance to cisplatin and carboplatin. International Journal of Oncology, 11, 539-542. https://doi.org/10.3892/ijo.11.3.539
MLA
Fink, D., Nebel, S., Aebi, S., Nehme, A., Howell, S."Loss of DNA mismatch repair due to knockout of MSH2 or PMS2 results in resistance to cisplatin and carboplatin". International Journal of Oncology 11.3 (1997): 539-542.
Chicago
Fink, D., Nebel, S., Aebi, S., Nehme, A., Howell, S."Loss of DNA mismatch repair due to knockout of MSH2 or PMS2 results in resistance to cisplatin and carboplatin". International Journal of Oncology 11, no. 3 (1997): 539-542. https://doi.org/10.3892/ijo.11.3.539
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