Oxygen radicals in lung carcinogenesis accompanying phagocytosis of diesel exhaust particles

Ichinose,T; Yamanushi,T; Seto,H; Sagai,M

doi:10.3892/ijo.11.3.571

September 1997 Volume 11 Issue 3

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September 1997 Volume 11 Issue 3

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Article

Oxygen radicals in lung carcinogenesis accompanying phagocytosis of diesel exhaust particles

Authors:
- T Ichinose
- T Yamanushi
- H Seto
- M Sagai
View Affiliations / Copyright

Affiliations: OCHANOMIZU UNIV, INST ENVIRONM SCI HUMAN LIFE, BUNKYO KU, TOKYO 112, JAPAN. TOKYO METROPOLITAN RES LAB PUBL HLTH, SHINJUKU KU, TOKYO 169, JAPAN.
Pages: 571-575
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Published online on: September 1, 1997

https://doi.org/10.3892/ijo.11.3.571
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Abstract

We sought to examine the involvement of oxygen radicals derived from phagocytosis process in lung carcinogenesis induced by diesel exhaust particles (DEP). The carcinogenic response and formation of 8-hydroxydeoxyguanosine (8-OHdG) were examined in the lungs of mice intratracheally injected with washed DEP (WDEP), DEP, or nontoxic control particles of titanium dioxide (TiO2). After 10 weekly treatments with these particles, the formation of 8-OHdG in the lungs of mice treated with WDEP or DEP showed a significant increase, but not in those treated with TiO2. After 12 months, the incidence of lung tumors in mice treated with WDEP or DEP was higher than that of mice treated with vehicle by 2.3- and 3.1-fold, respectively. A significant difference in the incidence of tumors was found between the vehicle group and DEP-treated group. Treatment with TiO2 had no effect on the incidence of lung tumors. The formation of 8-OHdG in mice treated with these particles was significantly correlated with the development of lung tumors. These results suggest that the induction of DNA damage by oxygen radicals may be an important factor in the initiation of WDEP- and DEP-induced lung carcinogenesis, and that oxygen radicals derived from the phagocytic process may play a role in 8-OHdG formation induced by DEP.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Oxygen radicals in lung carcinogenesis accompanying phagocytosis of diesel exhaust particles

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Abstract

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