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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1997 Volume 11 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1997 Volume 11 Issue 3

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Article

Effects of estrogen and tamoxifen on the MAP kinase cascade in experimental rat breast cancer

  • Authors:
    • Y Koibuchi
    • Y Iino
    • T Uchida
    • M Nagasawa
    • Y Morishita

  • View Affiliations / Copyright

    Affiliations: GUNMA UNIV,SCH MED,DEPT BIOCHEM,MAEBASHI,GUMMA 371,JAPAN. GUNMA UNIV,SCH MED,DEPT EMERGENCY & CRIT CARE MED,MAEBASHI,GUMMA 371,JAPAN.
  • Pages: 583-589
    |
    Published online on: September 1, 1997
       https://doi.org/10.3892/ijo.11.3.583
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Abstract

The mitogen-activated protein kinase (MAPK) cascade, which includes MAPK, MAP kinase kinase (MAPKK) and Raf-l, is involved in the signal transduction of growth factor receptors. We found that the MAPK and Raf-l proteins are increased in human breast cancer. Activated MAPKK was also observed. We then investigated whether the MAPK cascade is activated when 7,12-dimethylbenz(a) anthracene (DMBA)-induced rat mammary cancer is treated with 17 beta-estradiol (E-2). Ovariectomy suppressed MAPK expression in tumors, and E-2 administration induced the activation of MAPK in ovariectomized rats. We also investigated the effects of tamoxifen (TAM) on proliferation and the MAPK cascade in DMBA-induced rat mammary cancers. Although tumor size was reduced significantly by TAM, the expression of the MAPK and Raf-l proteins did not decrease. Additionally, MAPK and Raf-l protein expression increased in tumors of ovariectomized rats given TAM, despite a reduction in the size of the tumors. These results suggest that the activated MAPK cascade is important in human breast cancer, and is an important mechanism in the estrogen-dependent growth of DMBA-induced rat mammary cancer. TAM shows E-2-antagonistic effects on tumor proliferation, and E-2-agonistic effects on the MAPK cascade.

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Copy and paste a formatted citation
Spandidos Publications style
Koibuchi Y, Iino Y, Uchida T, Nagasawa M and Morishita Y: Effects of estrogen and tamoxifen on the MAP kinase cascade in experimental rat breast cancer. Int J Oncol 11: 583-589, 1997.
APA
Koibuchi, Y., Iino, Y., Uchida, T., Nagasawa, M., & Morishita, Y. (1997). Effects of estrogen and tamoxifen on the MAP kinase cascade in experimental rat breast cancer. International Journal of Oncology, 11, 583-589. https://doi.org/10.3892/ijo.11.3.583
MLA
Koibuchi, Y., Iino, Y., Uchida, T., Nagasawa, M., Morishita, Y."Effects of estrogen and tamoxifen on the MAP kinase cascade in experimental rat breast cancer". International Journal of Oncology 11.3 (1997): 583-589.
Chicago
Koibuchi, Y., Iino, Y., Uchida, T., Nagasawa, M., Morishita, Y."Effects of estrogen and tamoxifen on the MAP kinase cascade in experimental rat breast cancer". International Journal of Oncology 11, no. 3 (1997): 583-589. https://doi.org/10.3892/ijo.11.3.583
Copy and paste a formatted citation
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Spandidos Publications style
Koibuchi Y, Iino Y, Uchida T, Nagasawa M and Morishita Y: Effects of estrogen and tamoxifen on the MAP kinase cascade in experimental rat breast cancer. Int J Oncol 11: 583-589, 1997.
APA
Koibuchi, Y., Iino, Y., Uchida, T., Nagasawa, M., & Morishita, Y. (1997). Effects of estrogen and tamoxifen on the MAP kinase cascade in experimental rat breast cancer. International Journal of Oncology, 11, 583-589. https://doi.org/10.3892/ijo.11.3.583
MLA
Koibuchi, Y., Iino, Y., Uchida, T., Nagasawa, M., Morishita, Y."Effects of estrogen and tamoxifen on the MAP kinase cascade in experimental rat breast cancer". International Journal of Oncology 11.3 (1997): 583-589.
Chicago
Koibuchi, Y., Iino, Y., Uchida, T., Nagasawa, M., Morishita, Y."Effects of estrogen and tamoxifen on the MAP kinase cascade in experimental rat breast cancer". International Journal of Oncology 11, no. 3 (1997): 583-589. https://doi.org/10.3892/ijo.11.3.583
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