Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium

  • Authors:
    • S Reshkin
    • V Albarani
    • A Pezzetta
    • M Marinaccio
    • A Paradiso
  • View Affiliations

  • Published online on: September 1, 1997     https://doi.org/10.3892/ijo.11.3.603
  • Pages: 603-607
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Abstract

The present study evaluated the presence of GnRH-R in leiomyomas, in associated, non-involved uterine tissues (myometrium and endometrium) and the possible relationships between GnRH-R and the receptors for estrogen and progesterone in the same tissues. GnRH-R was found in all uterine tissues and both GnRH and the GnRH analog, goserelin, displaced its binding consistent with a single type of high affinity receptor (Kd approximate to 10(-8) M). GnRH-R were found more frequently in myometrium (81% of samples) than in endometrium (58%) or leiomyoma (42%). However, the mean receptor content was lowest in myometrium (139+/-19 fmol/mg protein) with both leiomyomas (288+/-77 fmol/mg protein) and endometrium (372+/-96 fmol/mg protein) having significantly higher values. Endometrial GnRH binding varied from 596+/-42 in uteri that were GnRH-R positive in the endothelium alone to 231+/-49 when GnRH-R was present also in the other tissues. Endometrium negative for the GnRH-R had significantly higher levels of estrogen receptor than all the other uterine samples (266+/-25 vs 61+/-7.5 fmol/mg protein, respectively). Endometrial GnRH-R seem to be dependent on its presence and/or level in other uterine tissues. Further, when GnRH-R is absent in the endometrium this tissue expresses greatly increased levels of steroid receptors.

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September 1997
Volume 11 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Reshkin S, Albarani V, Pezzetta A, Marinaccio M and Paradiso A: Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium. Int J Oncol 11: 603-607, 1997
APA
Reshkin, S., Albarani, V., Pezzetta, A., Marinaccio, M., & Paradiso, A. (1997). Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium. International Journal of Oncology, 11, 603-607. https://doi.org/10.3892/ijo.11.3.603
MLA
Reshkin, S., Albarani, V., Pezzetta, A., Marinaccio, M., Paradiso, A."Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium". International Journal of Oncology 11.3 (1997): 603-607.
Chicago
Reshkin, S., Albarani, V., Pezzetta, A., Marinaccio, M., Paradiso, A."Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium". International Journal of Oncology 11, no. 3 (1997): 603-607. https://doi.org/10.3892/ijo.11.3.603