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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1997 Volume 11 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1997 Volume 11 Issue 3

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Article

Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium

  • Authors:
    • S Reshkin
    • V Albarani
    • A Pezzetta
    • M Marinaccio
    • A Paradiso

  • View Affiliations / Copyright

    Affiliations: UNIV BARI,CLIN GINECOL 1,I-70126 BARI,ITALY. INST ONCOL,EXPT ONCOL LAB,BARI,ITALY.
  • Pages: 603-607
    |
    Published online on: September 1, 1997
       https://doi.org/10.3892/ijo.11.3.603
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Abstract

The present study evaluated the presence of GnRH-R in leiomyomas, in associated, non-involved uterine tissues (myometrium and endometrium) and the possible relationships between GnRH-R and the receptors for estrogen and progesterone in the same tissues. GnRH-R was found in all uterine tissues and both GnRH and the GnRH analog, goserelin, displaced its binding consistent with a single type of high affinity receptor (Kd approximate to 10(-8) M). GnRH-R were found more frequently in myometrium (81% of samples) than in endometrium (58%) or leiomyoma (42%). However, the mean receptor content was lowest in myometrium (139+/-19 fmol/mg protein) with both leiomyomas (288+/-77 fmol/mg protein) and endometrium (372+/-96 fmol/mg protein) having significantly higher values. Endometrial GnRH binding varied from 596+/-42 in uteri that were GnRH-R positive in the endothelium alone to 231+/-49 when GnRH-R was present also in the other tissues. Endometrium negative for the GnRH-R had significantly higher levels of estrogen receptor than all the other uterine samples (266+/-25 vs 61+/-7.5 fmol/mg protein, respectively). Endometrial GnRH-R seem to be dependent on its presence and/or level in other uterine tissues. Further, when GnRH-R is absent in the endometrium this tissue expresses greatly increased levels of steroid receptors.

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Copy and paste a formatted citation
Spandidos Publications style
Reshkin S, Albarani V, Pezzetta A, Marinaccio M and Paradiso A: Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium. Int J Oncol 11: 603-607, 1997.
APA
Reshkin, S., Albarani, V., Pezzetta, A., Marinaccio, M., & Paradiso, A. (1997). Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium. International Journal of Oncology, 11, 603-607. https://doi.org/10.3892/ijo.11.3.603
MLA
Reshkin, S., Albarani, V., Pezzetta, A., Marinaccio, M., Paradiso, A."Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium". International Journal of Oncology 11.3 (1997): 603-607.
Chicago
Reshkin, S., Albarani, V., Pezzetta, A., Marinaccio, M., Paradiso, A."Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium". International Journal of Oncology 11, no. 3 (1997): 603-607. https://doi.org/10.3892/ijo.11.3.603
Copy and paste a formatted citation
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Spandidos Publications style
Reshkin S, Albarani V, Pezzetta A, Marinaccio M and Paradiso A: Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium. Int J Oncol 11: 603-607, 1997.
APA
Reshkin, S., Albarani, V., Pezzetta, A., Marinaccio, M., & Paradiso, A. (1997). Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium. International Journal of Oncology, 11, 603-607. https://doi.org/10.3892/ijo.11.3.603
MLA
Reshkin, S., Albarani, V., Pezzetta, A., Marinaccio, M., Paradiso, A."Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium". International Journal of Oncology 11.3 (1997): 603-607.
Chicago
Reshkin, S., Albarani, V., Pezzetta, A., Marinaccio, M., Paradiso, A."Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium". International Journal of Oncology 11, no. 3 (1997): 603-607. https://doi.org/10.3892/ijo.11.3.603
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