p53 overexpression as a prognostic factor in patients with Dukes B colorectal adenocarcinoma

  • Authors:
    • Z Bartik
    • B Nordenskjold
    • X Sun
  • View Affiliations

  • Published online on: November 1, 1997     https://doi.org/10.3892/ijo.11.5.1019
  • Pages: 1019-1023
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Abstract

To investigate the relationship of p53 overexpression with clinicopathological factors and prognosis, we examined p53 expression in 257 colorectal adenocarcinomas by immunohistochemistry using monoclonal antibody DO-1. Nuclear p53 staining was detected in 113 tumors. p53 overexpression was increased in DNA non-diploid tumors (p=0.004) and in the tumors with higher proliferative activity (p=0.02). Overexpression of p53 predicted unfavorable prognosis in patients with Dukes B tumors in both univariate (p=0.02) and multivariate analyses including DNA ploidy (p=0.04). No correlation was found between p53 expression and patient sex and age, tumor site, stage, differentiation or growth pattern. Our results indicate that p53 overexpression detected by antibody DO-I might be a useful tool in optimizing care of patients with Dukes B tumors.

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November 1997
Volume 11 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Bartik Z, Nordenskjold B and Sun X: p53 overexpression as a prognostic factor in patients with Dukes B colorectal adenocarcinoma. Int J Oncol 11: 1019-1023, 1997.
APA
Bartik, Z., Nordenskjold, B., & Sun, X. (1997). p53 overexpression as a prognostic factor in patients with Dukes B colorectal adenocarcinoma. International Journal of Oncology, 11, 1019-1023. https://doi.org/10.3892/ijo.11.5.1019
MLA
Bartik, Z., Nordenskjold, B., Sun, X."p53 overexpression as a prognostic factor in patients with Dukes B colorectal adenocarcinoma". International Journal of Oncology 11.5 (1997): 1019-1023.
Chicago
Bartik, Z., Nordenskjold, B., Sun, X."p53 overexpression as a prognostic factor in patients with Dukes B colorectal adenocarcinoma". International Journal of Oncology 11, no. 5 (1997): 1019-1023. https://doi.org/10.3892/ijo.11.5.1019