Differential mechanisms of multidrug resistance are expressed during stepwise selection of KB-3-1 cells with adriamycin

  • Authors:
    • L Villagra
    • A Darling
    • D Yassa
    • R Scheper
    • T Tritton
    • A Bhushan
  • View Affiliations

  • Published online on: November 1, 1997     https://doi.org/10.3892/ijo.11.5.1025
  • Pages: 1025-1033
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A major limitation of cancer chemotherapy is development of resistance. In this study, we analyzed KB-3-1 cells and adriamycin-selected multidrug resistant sublines KB-A1 and KB-A10 cells for mechanisms of resistance. KB-A10 cells are 10-fold more resistant than KB-A1 cells but have lower P-glycoprotein. Of the known mechanisms of multidrug resistance, topoisomerase II and lung-resistance-related protein were altered between the resistant cell lines. Glutathione-S-transferase activity and multidrug-resistance-related protein levels were higher in the resistant cell lines compared to the sensitive cells but were similar in KB-A1 and KB-A10 cells. Results indicate differential regulation of mechanisms of resistance with stepwise selection.

Related Articles

Journal Cover

November 1997
Volume 11 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Villagra L, Darling A, Yassa D, Scheper R, Tritton T and Bhushan A: Differential mechanisms of multidrug resistance are expressed during stepwise selection of KB-3-1 cells with adriamycin. Int J Oncol 11: 1025-1033, 1997
APA
Villagra, L., Darling, A., Yassa, D., Scheper, R., Tritton, T., & Bhushan, A. (1997). Differential mechanisms of multidrug resistance are expressed during stepwise selection of KB-3-1 cells with adriamycin. International Journal of Oncology, 11, 1025-1033. https://doi.org/10.3892/ijo.11.5.1025
MLA
Villagra, L., Darling, A., Yassa, D., Scheper, R., Tritton, T., Bhushan, A."Differential mechanisms of multidrug resistance are expressed during stepwise selection of KB-3-1 cells with adriamycin". International Journal of Oncology 11.5 (1997): 1025-1033.
Chicago
Villagra, L., Darling, A., Yassa, D., Scheper, R., Tritton, T., Bhushan, A."Differential mechanisms of multidrug resistance are expressed during stepwise selection of KB-3-1 cells with adriamycin". International Journal of Oncology 11, no. 5 (1997): 1025-1033. https://doi.org/10.3892/ijo.11.5.1025