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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 1997 Volume 11 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 1997 Volume 11 Issue 6

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Article

Inhibition of migration of MDA-MB-231 cells by methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate (DIME)

  • Authors:
    • K Buki
    • E Kirsten
    • P Bauer
    • C Vidair
    • A Kun
    • J Mendeleyev
    • E Kun

  • View Affiliations / Copyright

    Affiliations: SAN FRANCISCO STATE UNIV,LAB ENVIRONM TOXICOL & CHEM,OCTAMER RES FDN,ROMBERG TIBURON CTR,TIBURON,CA 94920.
  • Pages: 1247-1250
    |
    Published online on: December 1, 1997
       https://doi.org/10.3892/ijo.11.6.1247
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Abstract

The GTPase activity of purified dimeric tubulin (alpha+beta) at 5 mu M was insensitive to methyl-3,5-diiodo-4-(4'-methoxyphenoxy) benzoate (DIME), in contrast to nocodazole which activated GTPase. Cellular motility of MDA-MB-231 (human mammary cancer) cells migrating through 12-mu m pores was inhibited by DIME similar to nocodazole in a drug concentration-and DIME structure-dependent manner. An increase of cytoplasmic ATPase activity of DIME-treated cells without a decrease in ATP contents of intact cells suggests that DIME may also influence additional as yet unidentified ATP-dependent system(s) probably also involved in cell motility. These results show that DIME not only arrests cells in M phase but also inhibits cell motility in interphase. However the cellular mode of action of DIME is different from the action of other toxic tubulin-targeted drugs, despite the fact that DIME in a concentration-dependent manner disrupts microtubule structures in intact cells.

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Copy and paste a formatted citation
Spandidos Publications style
Buki K, Kirsten E, Bauer P, Vidair C, Kun A, Mendeleyev J and Kun E: Inhibition of migration of MDA-MB-231 cells by methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate (DIME). Int J Oncol 11: 1247-1250, 1997.
APA
Buki, K., Kirsten, E., Bauer, P., Vidair, C., Kun, A., Mendeleyev, J., & Kun, E. (1997). Inhibition of migration of MDA-MB-231 cells by methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate (DIME). International Journal of Oncology, 11, 1247-1250. https://doi.org/10.3892/ijo.11.6.1247
MLA
Buki, K., Kirsten, E., Bauer, P., Vidair, C., Kun, A., Mendeleyev, J., Kun, E."Inhibition of migration of MDA-MB-231 cells by methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate (DIME)". International Journal of Oncology 11.6 (1997): 1247-1250.
Chicago
Buki, K., Kirsten, E., Bauer, P., Vidair, C., Kun, A., Mendeleyev, J., Kun, E."Inhibition of migration of MDA-MB-231 cells by methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate (DIME)". International Journal of Oncology 11, no. 6 (1997): 1247-1250. https://doi.org/10.3892/ijo.11.6.1247
Copy and paste a formatted citation
x
Spandidos Publications style
Buki K, Kirsten E, Bauer P, Vidair C, Kun A, Mendeleyev J and Kun E: Inhibition of migration of MDA-MB-231 cells by methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate (DIME). Int J Oncol 11: 1247-1250, 1997.
APA
Buki, K., Kirsten, E., Bauer, P., Vidair, C., Kun, A., Mendeleyev, J., & Kun, E. (1997). Inhibition of migration of MDA-MB-231 cells by methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate (DIME). International Journal of Oncology, 11, 1247-1250. https://doi.org/10.3892/ijo.11.6.1247
MLA
Buki, K., Kirsten, E., Bauer, P., Vidair, C., Kun, A., Mendeleyev, J., Kun, E."Inhibition of migration of MDA-MB-231 cells by methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate (DIME)". International Journal of Oncology 11.6 (1997): 1247-1250.
Chicago
Buki, K., Kirsten, E., Bauer, P., Vidair, C., Kun, A., Mendeleyev, J., Kun, E."Inhibition of migration of MDA-MB-231 cells by methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate (DIME)". International Journal of Oncology 11, no. 6 (1997): 1247-1250. https://doi.org/10.3892/ijo.11.6.1247
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