Human papillomavirus type 16 E5 protein (review)

  • Authors:
    • E Auvinen
    • K Crusius
    • B Steuer
    • A Alonso
  • View Affiliations

  • Published online on: December 1, 1997     https://doi.org/10.3892/ijo.11.6.1297
  • Pages: 1297-1304
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The association of certain human papillomavirus (HPV) types with malignancies of the anogenital tract is well established. The virus type most frequently associated with cellular transformation is HPV 16, as has been shown in epidemiological studies. Its transforming capacity has also been demonstrated in many in vitro cell transformation experiments. The most potent oncogenes of HPV 16 are the E6 and E7 proteins, but the E5 protein, whose homologue is the main oncogene of bovine papillomavirus, has recently been identified as an oncogene also for HPV. On the basis of epidemiological and clinical data from tumor material as well as from in vitro data it has been suggested, that the HPV 16 E5 protein would have a function at the early stages of cervical carcinogenesis. The E5 protein enhances growth factor-mediated signal transduction to the nucleus and consequently augments cellular proliferation. Expression of the E5 protein enables the infected cell to escape growth control provided by surrounding cells by inhibiting gap junctional intercellular communication in epithelial cells. This viral oncogene seems to interfere with the control mechanisms of cellular growth and proliferation and thus facilitate the function of the E6 and E7 proteins and further steps towards epithelial cell transformation.

Related Articles

Journal Cover

December 1997
Volume 11 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Auvinen E, Crusius K, Steuer B and Alonso A: Human papillomavirus type 16 E5 protein (review). Int J Oncol 11: 1297-1304, 1997
APA
Auvinen, E., Crusius, K., Steuer, B., & Alonso, A. (1997). Human papillomavirus type 16 E5 protein (review). International Journal of Oncology, 11, 1297-1304. https://doi.org/10.3892/ijo.11.6.1297
MLA
Auvinen, E., Crusius, K., Steuer, B., Alonso, A."Human papillomavirus type 16 E5 protein (review)". International Journal of Oncology 11.6 (1997): 1297-1304.
Chicago
Auvinen, E., Crusius, K., Steuer, B., Alonso, A."Human papillomavirus type 16 E5 protein (review)". International Journal of Oncology 11, no. 6 (1997): 1297-1304. https://doi.org/10.3892/ijo.11.6.1297