Biological and clinical significance of hepatocyte growth factor in breast cancer

  • Authors:
    • T Narita
    • N Kimura
    • C Mitsuoka
    • M Toi
    • M Sato
    • N Matsuura
    • K Matsumoto
    • T Nakamura
    • R Kannagi
  • View Affiliations

  • Published online on: December 1, 1997     https://doi.org/10.3892/ijo.11.6.1305
  • Pages: 1305-1310
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Abstract

Hepatocyte growth factor (HGF) is a mesenchyme- or stroma-derived multipotent factor that regulates the growth, motility, and morphogenesis of various types of cells, including cancer cells. We investigated the effect of HGF on human breast cancer cells, and measured the concentration of HGF in the sera of breast cancer patients. When BT-20 cells were stimulated with HGF, the transmigration of cancer cells was markedly accelerated. In a checkboard assay, pronounced chemotaxic locomotion of BT-20 cells is expressed, corresponding to HGF concentrations. HGF treatment of BT-20 cells resulted in enhanced expression of alpha 2, alpha 3 and beta 1 integrin subunits, and augmented the binding activity to immobilized collagen. The c-met protein was expressed on the cancer cells in 48 of the 97 (49.5%) breast cancer primary tumors. In the serum, the advanced and recurrent cancer group showed a high level of this protein in comparison with the other patient groups. The mean value of serum HGF was 0.65 ng/ml in patients with distant metastases and 0.27 ng/ml in those with no such evidence. Thus, the HGF concentration becomes significantly elevated in the sera of patients with distant metastases. These findings suggest that HGF is involved in invasion and metastasis of breast cancer, and that serum HGF is useful as a tumor marker with a close correlation to the metastatic state of breast cancer.

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December 1997
Volume 11 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Narita T, Kimura N, Mitsuoka C, Toi M, Sato M, Matsuura N, Matsumoto K, Nakamura T and Kannagi R: Biological and clinical significance of hepatocyte growth factor in breast cancer. Int J Oncol 11: 1305-1310, 1997
APA
Narita, T., Kimura, N., Mitsuoka, C., Toi, M., Sato, M., Matsuura, N. ... Kannagi, R. (1997). Biological and clinical significance of hepatocyte growth factor in breast cancer. International Journal of Oncology, 11, 1305-1310. https://doi.org/10.3892/ijo.11.6.1305
MLA
Narita, T., Kimura, N., Mitsuoka, C., Toi, M., Sato, M., Matsuura, N., Matsumoto, K., Nakamura, T., Kannagi, R."Biological and clinical significance of hepatocyte growth factor in breast cancer". International Journal of Oncology 11.6 (1997): 1305-1310.
Chicago
Narita, T., Kimura, N., Mitsuoka, C., Toi, M., Sato, M., Matsuura, N., Matsumoto, K., Nakamura, T., Kannagi, R."Biological and clinical significance of hepatocyte growth factor in breast cancer". International Journal of Oncology 11, no. 6 (1997): 1305-1310. https://doi.org/10.3892/ijo.11.6.1305