Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).

  • Authors:
    • D Decaudin
    • I Marzo
    • C Brenner
    • G Kroemer
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/ijo.12.1.141
  • Pages: 141-193
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Abstract

Resistance to apoptosis is a frequent characteristic of cancer cells and participates both in the initial phase of carcinogenesis and in the development of chemotherapy resistance. Recently, it has become clear that a disruption in mitochondrial membrane function is a decisive event of the apoptotic process leading to the disposal of chemotherapy-treated cells. Opening of the mitochondrial megachannel (also called permeability transition pore) is at least in part responsible for the disruption of mitochondrial membrane integrity in apoptosis. The megachannel is regulated by numerous endogenous effectors including members of the Bcl-2/Bax family, the redox status of the cell, cytosolic Ca2+ levels, ceramide, and amphipathic peptides. Chemotherapeutic agents may induce opening of the megachannel by modulating some of these endogenous effectors. The disruption of mitochondrial membrane integrity involves a loss of metabolic functions and the liberation of intermembrane proteins into the cytosol. Such proteins, which normally are well secluded in mitochondria, include cytochrome c and AIF (apoptosis inducing factor), which both activate caspases and endonucleases upon release into the cytosol. Strategies for the development of chemotherapeutic agents acting on mitochondria are discussed.

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Jan 1998
Volume 12 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Decaudin D, Marzo I, Brenner C and Kroemer G: Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).. Int J Oncol 12: 141-193, 1998
APA
Decaudin, D., Marzo, I., Brenner, C., & Kroemer, G. (1998). Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).. International Journal of Oncology, 12, 141-193. https://doi.org/10.3892/ijo.12.1.141
MLA
Decaudin, D., Marzo, I., Brenner, C., Kroemer, G."Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).". International Journal of Oncology 12.1 (1998): 141-193.
Chicago
Decaudin, D., Marzo, I., Brenner, C., Kroemer, G."Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).". International Journal of Oncology 12, no. 1 (1998): 141-193. https://doi.org/10.3892/ijo.12.1.141