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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Jan 1998 Volume 12 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jan 1998 Volume 12 Issue 1

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Article

Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).

  • Authors:
    • D Decaudin
    • I Marzo
    • C Brenner
    • G Kroemer
  • View Affiliations / Copyright

    Affiliations: Centre National de la Recherche Scientifique, Unité Propre de Recherche 420, 19 rue Guy Môquet, F-94801 Villejuif, France.
  • Pages: 141-193
    |
    Published online on: January 1, 1998
       https://doi.org/10.3892/ijo.12.1.141
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Abstract

Resistance to apoptosis is a frequent characteristic of cancer cells and participates both in the initial phase of carcinogenesis and in the development of chemotherapy resistance. Recently, it has become clear that a disruption in mitochondrial membrane function is a decisive event of the apoptotic process leading to the disposal of chemotherapy-treated cells. Opening of the mitochondrial megachannel (also called permeability transition pore) is at least in part responsible for the disruption of mitochondrial membrane integrity in apoptosis. The megachannel is regulated by numerous endogenous effectors including members of the Bcl-2/Bax family, the redox status of the cell, cytosolic Ca2+ levels, ceramide, and amphipathic peptides. Chemotherapeutic agents may induce opening of the megachannel by modulating some of these endogenous effectors. The disruption of mitochondrial membrane integrity involves a loss of metabolic functions and the liberation of intermembrane proteins into the cytosol. Such proteins, which normally are well secluded in mitochondria, include cytochrome c and AIF (apoptosis inducing factor), which both activate caspases and endonucleases upon release into the cytosol. Strategies for the development of chemotherapeutic agents acting on mitochondria are discussed.

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Copy and paste a formatted citation
Spandidos Publications style
Decaudin D, Marzo I, Brenner C and Kroemer G: Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).. Int J Oncol 12: 141-193, 1998.
APA
Decaudin, D., Marzo, I., Brenner, C., & Kroemer, G. (1998). Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).. International Journal of Oncology, 12, 141-193. https://doi.org/10.3892/ijo.12.1.141
MLA
Decaudin, D., Marzo, I., Brenner, C., Kroemer, G."Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).". International Journal of Oncology 12.1 (1998): 141-193.
Chicago
Decaudin, D., Marzo, I., Brenner, C., Kroemer, G."Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).". International Journal of Oncology 12, no. 1 (1998): 141-193. https://doi.org/10.3892/ijo.12.1.141
Copy and paste a formatted citation
x
Spandidos Publications style
Decaudin D, Marzo I, Brenner C and Kroemer G: Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).. Int J Oncol 12: 141-193, 1998.
APA
Decaudin, D., Marzo, I., Brenner, C., & Kroemer, G. (1998). Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).. International Journal of Oncology, 12, 141-193. https://doi.org/10.3892/ijo.12.1.141
MLA
Decaudin, D., Marzo, I., Brenner, C., Kroemer, G."Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).". International Journal of Oncology 12.1 (1998): 141-193.
Chicago
Decaudin, D., Marzo, I., Brenner, C., Kroemer, G."Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).". International Journal of Oncology 12, no. 1 (1998): 141-193. https://doi.org/10.3892/ijo.12.1.141
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