Mitogenic signaling by substance P and bombesin-like neuropeptide receptors in astrocytic/glial brain tumor-derived cell lines.

  • Authors:
    • M Sharif
  • View Affiliations

  • Published online on: February 1, 1998     https://doi.org/10.3892/ijo.12.2.273
  • Pages: 273-359
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Neuropeptides such as substance P (SP) and bombesin regulate many biological processes through binding to and activating their respective cell surface receptors. Recently, we reported that many astrocytic/glial-derived brain tumor cell lines express functional SP and bombesin receptors (43% and 85%, respectively). Activation of these neuropeptide receptors stimulates several signaling pathways that regulate transcription and translation leading to the induction of mitogenesis in several cell types including astrocytic brain tumor-derived cell lines. We have also shown that a number of signaling pathways are induced by SP and/or bombesin receptors in astrocytic/glial-derived brain tumor cell lines and demonstrated that inhibiting these path-ways by selective compounds such as PD 098059, tamoxifen, CGP 41251, and rapamycin blocks cell growth. In summary, mitogenic signaling by neuropeptides may play a role in brain tumor growth and/or tumor progression, and selective compounds capable of blocking mitogenic signaling have potential to be useful in the treatment of brain tumors.

Related Articles

Journal Cover

Feb 1998
Volume 12 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sharif M: Mitogenic signaling by substance P and bombesin-like neuropeptide receptors in astrocytic/glial brain tumor-derived cell lines.. Int J Oncol 12: 273-359, 1998.
APA
Sharif, M. (1998). Mitogenic signaling by substance P and bombesin-like neuropeptide receptors in astrocytic/glial brain tumor-derived cell lines.. International Journal of Oncology, 12, 273-359. https://doi.org/10.3892/ijo.12.2.273
MLA
Sharif, M."Mitogenic signaling by substance P and bombesin-like neuropeptide receptors in astrocytic/glial brain tumor-derived cell lines.". International Journal of Oncology 12.2 (1998): 273-359.
Chicago
Sharif, M."Mitogenic signaling by substance P and bombesin-like neuropeptide receptors in astrocytic/glial brain tumor-derived cell lines.". International Journal of Oncology 12, no. 2 (1998): 273-359. https://doi.org/10.3892/ijo.12.2.273