Spontaneous apoptosis in ovarian cancer: an unfavorable prognostic factor.

  • Authors:
    • J Mattern
    • G Stammler
    • R Koomagi
    • D Wallwiener
    • M Kaufmann
    • M Volm
  • View Affiliations

  • Published online on: February 1, 1998     https://doi.org/10.3892/ijo.12.2.351
  • Pages: 351-355
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Abstract

Apoptosis and cell proliferation play important roles in the cellular response to chemotherapy, and may have prognostic value. The percentage of apoptotic cells [apoptotic index (AI)] was evaluated in ovarian carcinomas of 25 patients by the terminal desoxynucleotidyl transferase-mediated dUTP-nick end labeling (TUNEL) technique. All patients were surgically treated and received postoperatively chemotherapy consisting of cytoxan and cisplatin or carboplatin. As a marker of proliferation the mRNA expression of histone H3 in tumor tissue was determined. In addition, tumor vascularity was assessed by immunohistochemistry and factor VIII. Patients with high AI had significantly shorter survival times (p=0. 0001) or recurrence-free intervals (p=0.004) than patients with low AI. No significant relationship was found between AI and histone H3 mRNA expression, however, an inverse correlation of AI with microvessel density was detected. Tumors with high AI had significantly lower microvessel count than tumors with low AI (p=0. 002). The obtained data suggest that AI can be predictive of treatment outcome in ovarian cancer.

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Feb 1998
Volume 12 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Mattern J, Stammler G, Koomagi R, Wallwiener D, Kaufmann M and Volm M: Spontaneous apoptosis in ovarian cancer: an unfavorable prognostic factor.. Int J Oncol 12: 351-355, 1998
APA
Mattern, J., Stammler, G., Koomagi, R., Wallwiener, D., Kaufmann, M., & Volm, M. (1998). Spontaneous apoptosis in ovarian cancer: an unfavorable prognostic factor.. International Journal of Oncology, 12, 351-355. https://doi.org/10.3892/ijo.12.2.351
MLA
Mattern, J., Stammler, G., Koomagi, R., Wallwiener, D., Kaufmann, M., Volm, M."Spontaneous apoptosis in ovarian cancer: an unfavorable prognostic factor.". International Journal of Oncology 12.2 (1998): 351-355.
Chicago
Mattern, J., Stammler, G., Koomagi, R., Wallwiener, D., Kaufmann, M., Volm, M."Spontaneous apoptosis in ovarian cancer: an unfavorable prognostic factor.". International Journal of Oncology 12, no. 2 (1998): 351-355. https://doi.org/10.3892/ijo.12.2.351