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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Feb 1998 Volume 12 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Feb 1998 Volume 12 Issue 2

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Article

Immunogenicity, immunosensitivity and cell surface adhesiveness of tumour vaccines carrying an inserted CD80 gene.

  • Authors:
    • M Indrova
    • J Bubenik
    • P Rossner
    • J Zeuthen
    • T Jandlova
    • V Sobota

  • View Affiliations / Copyright

    Affiliations: Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 166 37 Prague 6, Czech Republic.
  • Pages: 387-477
    |
    Published online on: February 1, 1998
       https://doi.org/10.3892/ijo.12.2.387
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Abstract

Cell surface adhesiveness, immunogenicity and immunosensitivity of tumour vaccines modified by the CD80 gene transfection was examined and compared to that of the parental MC12 murine sarcoma. Insertion of the CD80 gene substantially enhanced the adhesiveness of the genetically modified tumour cells to nylon wool non-adherent (T) but not to nylon wool adherent (B) lymphocytes. The increased adhesive interaction could be inhibited by anti-CD80 monoclonal antibody. CD80+ transfectants were more sensitive to the cytotolytic effect of MC12-immune splenocytes and IL-2-activated spleen cells than the parental MC12 sarcoma. Similarly, spleen cells from syngeneic mice immunized with CD80+ transfectants displayed a higher cytolytic activity when allowed to react with MC12 cells than splenocytes from mice immunized with the parental MC12 cells. These results suggest that a positive correlation exists among the expression of the CD80 molecules, T cell adhesion to the genetically modified cells, immunosensitivity of the CD80+ transfectants and the capacity of the transfectants to activate cytolytic, tumour-reactive effector cells in vivo. This correlation provides a rationale for gene therapy based on the construction of CD80- modified tumour vaccines.

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Copy and paste a formatted citation
Spandidos Publications style
Indrova M, Bubenik J, Rossner P, Zeuthen J, Jandlova T and Sobota V: Immunogenicity, immunosensitivity and cell surface adhesiveness of tumour vaccines carrying an inserted CD80 gene.. Int J Oncol 12: 387-477, 1998.
APA
Indrova, M., Bubenik, J., Rossner, P., Zeuthen, J., Jandlova, T., & Sobota, V. (1998). Immunogenicity, immunosensitivity and cell surface adhesiveness of tumour vaccines carrying an inserted CD80 gene.. International Journal of Oncology, 12, 387-477. https://doi.org/10.3892/ijo.12.2.387
MLA
Indrova, M., Bubenik, J., Rossner, P., Zeuthen, J., Jandlova, T., Sobota, V."Immunogenicity, immunosensitivity and cell surface adhesiveness of tumour vaccines carrying an inserted CD80 gene.". International Journal of Oncology 12.2 (1998): 387-477.
Chicago
Indrova, M., Bubenik, J., Rossner, P., Zeuthen, J., Jandlova, T., Sobota, V."Immunogenicity, immunosensitivity and cell surface adhesiveness of tumour vaccines carrying an inserted CD80 gene.". International Journal of Oncology 12, no. 2 (1998): 387-477. https://doi.org/10.3892/ijo.12.2.387
Copy and paste a formatted citation
x
Spandidos Publications style
Indrova M, Bubenik J, Rossner P, Zeuthen J, Jandlova T and Sobota V: Immunogenicity, immunosensitivity and cell surface adhesiveness of tumour vaccines carrying an inserted CD80 gene.. Int J Oncol 12: 387-477, 1998.
APA
Indrova, M., Bubenik, J., Rossner, P., Zeuthen, J., Jandlova, T., & Sobota, V. (1998). Immunogenicity, immunosensitivity and cell surface adhesiveness of tumour vaccines carrying an inserted CD80 gene.. International Journal of Oncology, 12, 387-477. https://doi.org/10.3892/ijo.12.2.387
MLA
Indrova, M., Bubenik, J., Rossner, P., Zeuthen, J., Jandlova, T., Sobota, V."Immunogenicity, immunosensitivity and cell surface adhesiveness of tumour vaccines carrying an inserted CD80 gene.". International Journal of Oncology 12.2 (1998): 387-477.
Chicago
Indrova, M., Bubenik, J., Rossner, P., Zeuthen, J., Jandlova, T., Sobota, V."Immunogenicity, immunosensitivity and cell surface adhesiveness of tumour vaccines carrying an inserted CD80 gene.". International Journal of Oncology 12, no. 2 (1998): 387-477. https://doi.org/10.3892/ijo.12.2.387
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