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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Mar 1998 Volume 12 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Mar 1998 Volume 12 Issue 3

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Article

Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia.

  • Authors:
    • T Otsuki
    • N Nakazawa
    • M Taniwaki
    • O Yamada
    • H Sakaguchi
    • H Wada
    • Y Yawata
    • A Ueki
  • View Affiliations / Copyright

    Affiliations: Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-01, Japan.
  • Pages: 545-597
    |
    Published online on: March 1, 1998
       https://doi.org/10.3892/ijo.12.3.545
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Abstract

A new human myeloma cell line, KMS-18, was established from a 58-year-old male with multiple myeloma associated with hyperammonemia. The original leukemic cells and established KMS-18 cells possessed several of the same chromosomal abnormalities, including add(1)(q32), add(10) (q24) and add(17)(p11). In addition, the KMS-18 cells showed novel t(4;14)(p16.3;q32.3) masked translocation which was determined by the FISH method. Moreover, we compared the ammonia production in culture medium of the KMS-18 cell line with that of non-myeloma hematological malignant cell lines and a hepatocellular carcinoma cell line. KMS-18 produced higher levels of ammonia in medium than the other cell lines examined. This new cell line may prove helpful in analyzing the role and biological mechanisms of the t(4;14)(p16.3;q32.3) translocation in myeloma and also in investigating hyperammonemia in cases with myeloma.

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Copy and paste a formatted citation
Spandidos Publications style
Otsuki T, Nakazawa N, Taniwaki M, Yamada O, Sakaguchi H, Wada H, Yawata Y and Ueki A: Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia.. Int J Oncol 12: 545-597, 1998.
APA
Otsuki, T., Nakazawa, N., Taniwaki, M., Yamada, O., Sakaguchi, H., Wada, H. ... Ueki, A. (1998). Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia.. International Journal of Oncology, 12, 545-597. https://doi.org/10.3892/ijo.12.3.545
MLA
Otsuki, T., Nakazawa, N., Taniwaki, M., Yamada, O., Sakaguchi, H., Wada, H., Yawata, Y., Ueki, A."Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia.". International Journal of Oncology 12.3 (1998): 545-597.
Chicago
Otsuki, T., Nakazawa, N., Taniwaki, M., Yamada, O., Sakaguchi, H., Wada, H., Yawata, Y., Ueki, A."Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia.". International Journal of Oncology 12, no. 3 (1998): 545-597. https://doi.org/10.3892/ijo.12.3.545
Copy and paste a formatted citation
x
Spandidos Publications style
Otsuki T, Nakazawa N, Taniwaki M, Yamada O, Sakaguchi H, Wada H, Yawata Y and Ueki A: Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia.. Int J Oncol 12: 545-597, 1998.
APA
Otsuki, T., Nakazawa, N., Taniwaki, M., Yamada, O., Sakaguchi, H., Wada, H. ... Ueki, A. (1998). Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia.. International Journal of Oncology, 12, 545-597. https://doi.org/10.3892/ijo.12.3.545
MLA
Otsuki, T., Nakazawa, N., Taniwaki, M., Yamada, O., Sakaguchi, H., Wada, H., Yawata, Y., Ueki, A."Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia.". International Journal of Oncology 12.3 (1998): 545-597.
Chicago
Otsuki, T., Nakazawa, N., Taniwaki, M., Yamada, O., Sakaguchi, H., Wada, H., Yawata, Y., Ueki, A."Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia.". International Journal of Oncology 12, no. 3 (1998): 545-597. https://doi.org/10.3892/ijo.12.3.545
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