Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients.

Murata,M; Tagawa,M; Kimura,H; Kakisawa,K; Shirasawa,H; Fujisawa,T

doi:10.3892/ijo.12.3.577

Mar 1998 Volume 12 Issue 3

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Mar 1998 Volume 12 Issue 3

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Article

Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients.

Authors:
- M Murata
- M Tagawa
- H Kimura
- K Kakisawa
- H Shirasawa
- T Fujisawa
View Affiliations / Copyright

Affiliations: Division of Epidemiology, Chiba Cancer Center Research Institute, 666-2, Nitona, Chuo-ku, Chiba, 260, Japan.
Pages: 577-658
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Published online on: March 1, 1998

https://doi.org/10.3892/ijo.12.3.577
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Abstract

The polymorphism of p53 gene at codon 72 consisting of either arginine (Arg)- or proline (Pro)-encoded allele is suggested to be associated with the susceptibility of tobacco-related lung cancer. In this study we examined the polymorphism of 224 non-small cell lung cancer (NSCLC) patients and that of 303 control persons with a polymerase chain reaction method and found that Pro-allele carriers were significantly more frequent in those patients who smoked and were affected at a younger age (<65) (P<0.05). We also investigated whether the mutational alterations of this gene could be influenced by the genotype. The overall mutation rate of 114 NSCLC patients examined with a single-strand conformation polymorphism method was 31%, which agreed with previous reports. However, the mutation rate was significantly increased in those patients who smoked and were affected at a younger age (<65) (P<0.05). Although the Pro-allele carriers among the smoker patients showed higher mutation rate than the Arg/Arg homozygotes, the difference between the genotypes had marginal significance (0.1

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients.

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Abstract

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