Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients.

  • Authors:
    • M Murata
    • M Tagawa
    • H Kimura
    • K Kakisawa
    • H Shirasawa
    • T Fujisawa
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijo.12.3.577
  • Pages: 577-658
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Abstract

The polymorphism of p53 gene at codon 72 consisting of either arginine (Arg)- or proline (Pro)-encoded allele is suggested to be associated with the susceptibility of tobacco-related lung cancer. In this study we examined the polymorphism of 224 non-small cell lung cancer (NSCLC) patients and that of 303 control persons with a polymerase chain reaction method and found that Pro-allele carriers were significantly more frequent in those patients who smoked and were affected at a younger age (<65) (P<0.05). We also investigated whether the mutational alterations of this gene could be influenced by the genotype. The overall mutation rate of 114 NSCLC patients examined with a single-strand conformation polymorphism method was 31%, which agreed with previous reports. However, the mutation rate was significantly increased in those patients who smoked and were affected at a younger age (<65) (P<0.05). Although the Pro-allele carriers among the smoker patients showed higher mutation rate than the Arg/Arg homozygotes, the difference between the genotypes had marginal significance (0.1

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Mar 1998
Volume 12 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Murata M, Tagawa M, Kimura H, Kakisawa K, Shirasawa H and Fujisawa T: Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients.. Int J Oncol 12: 577-658, 1998
APA
Murata, M., Tagawa, M., Kimura, H., Kakisawa, K., Shirasawa, H., & Fujisawa, T. (1998). Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients.. International Journal of Oncology, 12, 577-658. https://doi.org/10.3892/ijo.12.3.577
MLA
Murata, M., Tagawa, M., Kimura, H., Kakisawa, K., Shirasawa, H., Fujisawa, T."Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients.". International Journal of Oncology 12.3 (1998): 577-658.
Chicago
Murata, M., Tagawa, M., Kimura, H., Kakisawa, K., Shirasawa, H., Fujisawa, T."Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients.". International Journal of Oncology 12, no. 3 (1998): 577-658. https://doi.org/10.3892/ijo.12.3.577