HL60 cells exhibit particular ultrastructural features during all-trans retinoic acid-induced apoptosis.

  • Authors:
    • H Bobichon
    • P Mayer
    • Y Carpentier
    • B Desoize
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijo.12.3.649
  • Pages: 649-702
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Abstract

Ultrastructural features induced by 1 micromol/l all-trans retinoic acid (ATRA) treatment of HL60 cells were observed with transmission electron microscopy. Whilst some cells were unaffected, most of the others underwent granulocytic differentiation, starting point for apoptosis and then, possibly, secondary necrosis. First steps of apoptosis led to nuclear fragmentation into dense bodies. Then three different ways were observed: i) cells shrank and dense bodies were expelled, mostly associated with a fine lamellae of cytoplasm, ii) a secondary necrosis involved the release of apoptotic bodies without cytoplasm or iii) cells showed a dual or bipolar structure, not previously described.

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Mar 1998
Volume 12 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Bobichon H, Mayer P, Carpentier Y and Desoize B: HL60 cells exhibit particular ultrastructural features during all-trans retinoic acid-induced apoptosis.. Int J Oncol 12: 649-702, 1998
APA
Bobichon, H., Mayer, P., Carpentier, Y., & Desoize, B. (1998). HL60 cells exhibit particular ultrastructural features during all-trans retinoic acid-induced apoptosis.. International Journal of Oncology, 12, 649-702. https://doi.org/10.3892/ijo.12.3.649
MLA
Bobichon, H., Mayer, P., Carpentier, Y., Desoize, B."HL60 cells exhibit particular ultrastructural features during all-trans retinoic acid-induced apoptosis.". International Journal of Oncology 12.3 (1998): 649-702.
Chicago
Bobichon, H., Mayer, P., Carpentier, Y., Desoize, B."HL60 cells exhibit particular ultrastructural features during all-trans retinoic acid-induced apoptosis.". International Journal of Oncology 12, no. 3 (1998): 649-702. https://doi.org/10.3892/ijo.12.3.649