Hepatocyte growth factor enhances the invasion activity of human hepatocellular carcinoma cell lines.

  • Authors:
    • T Kamiyama
    • Y Une
    • J Uchino
    • J Hamada
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijo.12.3.655
  • Pages: 655-664
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Abstract

We investigated whether hepatocyte growth factor (HGF) enhances the invasion activity of three human HCC cell lines, HLF, HLE, and HC-4, in vitro. The analysis of the invasiveness consisted of the production of u-PA and the chemotaxis for fibronectin. Invasion activity of all cell lines was enhanced by the addition of recombinant human hepatocyte growth factor (rhHGF) to the medium. HGF stimulated the production of u-PA in HLF cells. HGF accelerated the chemotaxis of HC-4 and HLE. These data suggest that HGF increase the invasion activity of human HCC cell lines by affecting the production of u-PA or the chemotaxis for fibronectin.

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Mar 1998
Volume 12 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kamiyama T, Une Y, Uchino J and Hamada J: Hepatocyte growth factor enhances the invasion activity of human hepatocellular carcinoma cell lines.. Int J Oncol 12: 655-664, 1998.
APA
Kamiyama, T., Une, Y., Uchino, J., & Hamada, J. (1998). Hepatocyte growth factor enhances the invasion activity of human hepatocellular carcinoma cell lines.. International Journal of Oncology, 12, 655-664. https://doi.org/10.3892/ijo.12.3.655
MLA
Kamiyama, T., Une, Y., Uchino, J., Hamada, J."Hepatocyte growth factor enhances the invasion activity of human hepatocellular carcinoma cell lines.". International Journal of Oncology 12.3 (1998): 655-664.
Chicago
Kamiyama, T., Une, Y., Uchino, J., Hamada, J."Hepatocyte growth factor enhances the invasion activity of human hepatocellular carcinoma cell lines.". International Journal of Oncology 12, no. 3 (1998): 655-664. https://doi.org/10.3892/ijo.12.3.655