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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Apr 1998 Volume 12 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Apr 1998 Volume 12 Issue 4

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Article

Expression level of G1-cyclins and cell proliferation in human cultured leukemia/lymphoma cell lines.

  • Authors:
    • M Hirose
    • E Shimizu
    • H Nakanishi
    • A Shinohara
    • S Sone
    • Y Kuroda
  • View Affiliations / Copyright

    Affiliations: Division of Transfusion Medicine, School of Medicine, The University of Tokushima, Kuramoto-cho 2-50, Tokushima-City, Tokushima 770, Japan.
  • Pages: 841-847
    |
    Published online on: April 1, 1998
       https://doi.org/10.3892/ijo.12.4.841
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Abstract

We observed the expression of wild-type retinoblastoma protein (RB) in all 17 hematologic cultured cell lines tested. However, no p16INK4 expression was detected in any cell line among 16 leukemia/lymphoma cell lines, although an EBV-transformed cell line expressed p16INK4. The expression levels of cyclin D1 and CDK4 varied widely among the cell lines. The correlation coefficient (r2) between doubling time (DT) and cyclin D1 in the 14 cell lines that doubled within 47.2 h was 0.4856, while the r2 between DT and cyclin dependent kinase 4 (CDK4) and that between DT and RB among those cell lines were 0.3761 and 0.0874, respectively. The levels of protein expression in vincristine (VCR)-resistant cell lines was not different from those in corresponding wild-type cell lines. Thus, we concluded that the loss of p16INK4 protein and inactivation of RB protein could be an essential step for oncogenesis of leukemia/ lymphoma, and that cyclin D1 may possibly be a target protein to control cell growth of hematologic cell lines which lack the expression of p16INK4.

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Copy and paste a formatted citation
Spandidos Publications style
Hirose M, Shimizu E, Nakanishi H, Shinohara A, Sone S and Kuroda Y: Expression level of G1-cyclins and cell proliferation in human cultured leukemia/lymphoma cell lines.. Int J Oncol 12: 841-847, 1998.
APA
Hirose, M., Shimizu, E., Nakanishi, H., Shinohara, A., Sone, S., & Kuroda, Y. (1998). Expression level of G1-cyclins and cell proliferation in human cultured leukemia/lymphoma cell lines.. International Journal of Oncology, 12, 841-847. https://doi.org/10.3892/ijo.12.4.841
MLA
Hirose, M., Shimizu, E., Nakanishi, H., Shinohara, A., Sone, S., Kuroda, Y."Expression level of G1-cyclins and cell proliferation in human cultured leukemia/lymphoma cell lines.". International Journal of Oncology 12.4 (1998): 841-847.
Chicago
Hirose, M., Shimizu, E., Nakanishi, H., Shinohara, A., Sone, S., Kuroda, Y."Expression level of G1-cyclins and cell proliferation in human cultured leukemia/lymphoma cell lines.". International Journal of Oncology 12, no. 4 (1998): 841-847. https://doi.org/10.3892/ijo.12.4.841
Copy and paste a formatted citation
x
Spandidos Publications style
Hirose M, Shimizu E, Nakanishi H, Shinohara A, Sone S and Kuroda Y: Expression level of G1-cyclins and cell proliferation in human cultured leukemia/lymphoma cell lines.. Int J Oncol 12: 841-847, 1998.
APA
Hirose, M., Shimizu, E., Nakanishi, H., Shinohara, A., Sone, S., & Kuroda, Y. (1998). Expression level of G1-cyclins and cell proliferation in human cultured leukemia/lymphoma cell lines.. International Journal of Oncology, 12, 841-847. https://doi.org/10.3892/ijo.12.4.841
MLA
Hirose, M., Shimizu, E., Nakanishi, H., Shinohara, A., Sone, S., Kuroda, Y."Expression level of G1-cyclins and cell proliferation in human cultured leukemia/lymphoma cell lines.". International Journal of Oncology 12.4 (1998): 841-847.
Chicago
Hirose, M., Shimizu, E., Nakanishi, H., Shinohara, A., Sone, S., Kuroda, Y."Expression level of G1-cyclins and cell proliferation in human cultured leukemia/lymphoma cell lines.". International Journal of Oncology 12, no. 4 (1998): 841-847. https://doi.org/10.3892/ijo.12.4.841
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