Six novel mutations in the NF2 tumor suppressor gene.
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- Published online on: April 1, 1998 https://doi.org/10.3892/ijo.12.4.935
- Pages: 935-943
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Abstract
Six novel mutations were identified in the NF2 tumor suppressor gene in a panel of meningiomas and neurinomas. Screening was performed using a combination of single-strand conformation polymorphism and heteroduplex analyses on polymerase chain reaction-amplified DNA from tumors and matched peripheral blood lymphocytes. Mutations involved exons 2, 7, 11 and 12, and corresponded to three frameshift, one nonsense, one missense and one polymorphism.