Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines.

  • Authors:
    • M A McGuckin
    • R J Quin
    • B G Ward
  • View Affiliations

  • Published online on: April 1, 1998     https://doi.org/10.3892/ijo.12.4.939
  • Pages: 939-984
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Abstract

The effects of oestrogen and progesterone on expression of the MUC1 epithelial mucin were examined in MCF7 and ZR-75-1 breast cancer cells grown in steroid-free medium. Oestrogen caused an increase in cell growth and both cellular and secreted MUC1 in both cell lines. However, after correcting for increases in cellular protein, there was no clear changes. Progesterone, in combination with oestrogen, caused significant increases (over 2-fold, P<0.01) in cellular and secreted MUC1 when compared with oestrogen alone in both cell lines despite no or small increases in cellular protein. Growth of ZR-75-1 cells in a competitive inhibitor of O-glycosylation demonstrated that the increased detection by ELISA was not due to altered glycosylation. Progesterone may modulate expression of MUC1 in steroid-responsive breast cancer cells.

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Apr 1998
Volume 12 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
McGuckin M, Quin R and Ward B: Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines.. Int J Oncol 12: 939-984, 1998.
APA
McGuckin, M., Quin, R., & Ward, B. (1998). Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines.. International Journal of Oncology, 12, 939-984. https://doi.org/10.3892/ijo.12.4.939
MLA
McGuckin, M., Quin, R., Ward, B."Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines.". International Journal of Oncology 12.4 (1998): 939-984.
Chicago
McGuckin, M., Quin, R., Ward, B."Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines.". International Journal of Oncology 12, no. 4 (1998): 939-984. https://doi.org/10.3892/ijo.12.4.939