nm23 expression in human breast cancer: correlation with cell proliferation (S-phase) as observed with a double-labeling immunocytochemical-autoradiographic technique.

  • Authors:
    • G Simone
    • A Mangia
    • S Petroni
    • I Trotti
    • A Paradiso
    • F Marzullo
    • M De Lena
    • A Leone
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/ijo.12.5.1055
  • Pages: 1055-1064
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Abstract

In 51 unselected breast cancer samples, a double-labeling immunocytochemical technique was utilized to observe the phenotypic expression of the nm23 gene during S-phase. The feasibility of the method was confirmed by comparison with routine evaluations for both thymidine-labeling index and nm23 (p<0.001). No correlation was found between the two parameters in the overall series or when subgroups regarding menopausal status, nodal involvement, tumor size, hormone receptor content were considered. Tumors with a higher nuclear grade showed a significant correlation only with TLI (p=0. 02). A trend for an inverse relationship between the two parameters was noted but was not statistically significant. A significant association between TLI and nm23 expression was found by Chi-square test using median values as cut-off. Our data based on morphological and in situ observations do not confirm a correlation between nm23 and cell proliferation, even if this correlation cannot be completely excluded. Multicentric trials of high power with these same techniques are still necessary to definitely establish the prognostic role of nm23 in breast cancer.

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May 1998
Volume 12 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Simone G, Mangia A, Petroni S, Trotti I, Paradiso A, Marzullo F, De Lena M and Leone A: nm23 expression in human breast cancer: correlation with cell proliferation (S-phase) as observed with a double-labeling immunocytochemical-autoradiographic technique.. Int J Oncol 12: 1055-1064, 1998
APA
Simone, G., Mangia, A., Petroni, S., Trotti, I., Paradiso, A., Marzullo, F. ... Leone, A. (1998). nm23 expression in human breast cancer: correlation with cell proliferation (S-phase) as observed with a double-labeling immunocytochemical-autoradiographic technique.. International Journal of Oncology, 12, 1055-1064. https://doi.org/10.3892/ijo.12.5.1055
MLA
Simone, G., Mangia, A., Petroni, S., Trotti, I., Paradiso, A., Marzullo, F., De Lena, M., Leone, A."nm23 expression in human breast cancer: correlation with cell proliferation (S-phase) as observed with a double-labeling immunocytochemical-autoradiographic technique.". International Journal of Oncology 12.5 (1998): 1055-1064.
Chicago
Simone, G., Mangia, A., Petroni, S., Trotti, I., Paradiso, A., Marzullo, F., De Lena, M., Leone, A."nm23 expression in human breast cancer: correlation with cell proliferation (S-phase) as observed with a double-labeling immunocytochemical-autoradiographic technique.". International Journal of Oncology 12, no. 5 (1998): 1055-1064. https://doi.org/10.3892/ijo.12.5.1055