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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Jun 1998 Volume 12 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jun 1998 Volume 12 Issue 6

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Article

The tetramerization domain-independent Ras activation by BCR-ABL oncoprotein in hematopoietic cells.

  • Authors:
    • T Tauchi
    • S Okabe
    • K Miyazawa
    • K Ohyashiki
  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Tokyo Medical College, Tokyo 160, Japan.
  • Pages: 1269-1345
    |
    Published online on: June 1, 1998
       https://doi.org/10.3892/ijo.12.6.1269
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Abstract

BCR-ABL is a chimeric oncoprotein that exhibits deregulated tyrosine kinase activity and is implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias. We have previously shown that BCR-ABL activates Ras signaling pathways required for transformation. To elucidate the mechanisms whereby BCR-ABL induced transformation in hematopoietic cells, we examined the biological effects of expression of a series of BCR-ABL mutants. We found that the Grb2 binding site-deleted BCR-ABL and the SH2 domain-deleted BCR-ABL, as well as the tetramerization domain-deleted BCR-ABL do not diminish the transforming properties of BCR-ABL in hematopoietic cells, although these mutations were previously shown to drastically reduce the transforming activity of BCR-ABL in fibroblasts. The tetramerization domain-deleted BCR-ABL did not induce tyrosine phosphorylation of CrkL, SHP-2, Vav and the interactions of BCR-ABL and Shc. However, Ras is activated, Shc is tyrosine phosphorylated and binds to Grb2 in the tetramerization domain-deleted BCR-ABL expressing hematopoietic cells. These results suggest that the tetramerization domain-independent Ras activation is mediated by Shc proteins and induces the transformation of hematopoietic cells.

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Copy and paste a formatted citation
Spandidos Publications style
Tauchi T, Okabe S, Miyazawa K and Ohyashiki K: The tetramerization domain-independent Ras activation by BCR-ABL oncoprotein in hematopoietic cells.. Int J Oncol 12: 1269-1345, 1998.
APA
Tauchi, T., Okabe, S., Miyazawa, K., & Ohyashiki, K. (1998). The tetramerization domain-independent Ras activation by BCR-ABL oncoprotein in hematopoietic cells.. International Journal of Oncology, 12, 1269-1345. https://doi.org/10.3892/ijo.12.6.1269
MLA
Tauchi, T., Okabe, S., Miyazawa, K., Ohyashiki, K."The tetramerization domain-independent Ras activation by BCR-ABL oncoprotein in hematopoietic cells.". International Journal of Oncology 12.6 (1998): 1269-1345.
Chicago
Tauchi, T., Okabe, S., Miyazawa, K., Ohyashiki, K."The tetramerization domain-independent Ras activation by BCR-ABL oncoprotein in hematopoietic cells.". International Journal of Oncology 12, no. 6 (1998): 1269-1345. https://doi.org/10.3892/ijo.12.6.1269
Copy and paste a formatted citation
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Spandidos Publications style
Tauchi T, Okabe S, Miyazawa K and Ohyashiki K: The tetramerization domain-independent Ras activation by BCR-ABL oncoprotein in hematopoietic cells.. Int J Oncol 12: 1269-1345, 1998.
APA
Tauchi, T., Okabe, S., Miyazawa, K., & Ohyashiki, K. (1998). The tetramerization domain-independent Ras activation by BCR-ABL oncoprotein in hematopoietic cells.. International Journal of Oncology, 12, 1269-1345. https://doi.org/10.3892/ijo.12.6.1269
MLA
Tauchi, T., Okabe, S., Miyazawa, K., Ohyashiki, K."The tetramerization domain-independent Ras activation by BCR-ABL oncoprotein in hematopoietic cells.". International Journal of Oncology 12.6 (1998): 1269-1345.
Chicago
Tauchi, T., Okabe, S., Miyazawa, K., Ohyashiki, K."The tetramerization domain-independent Ras activation by BCR-ABL oncoprotein in hematopoietic cells.". International Journal of Oncology 12, no. 6 (1998): 1269-1345. https://doi.org/10.3892/ijo.12.6.1269
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