Synergistic anti-tumor effect of 13-cRA and IFN-alpha/beta in mouse renal cell carcinoma.

  • Authors:
    • I Taguchi
    • I Hara
    • K Gohji
    • S Arakawa
    • S Kamidono
  • View Affiliations

  • Published online on: July 1, 1998     https://doi.org/10.3892/ijo.13.1.145
  • Pages: 145-154
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Abstract

The synergistic anti-tumor effect of 13-cis retinoic acid (13-cRA) and interferon-alpha/beta (IFN-alpha/beta) was investigated using a highly metastatic mouse renal cell carcinoma cell subline (RenCa/F). Although 13-cRA inhibited tumor growth in vivo as well as in vitro, IFN-alpha/beta did not. Combined administration of 13-cRA and IFN-alpha/beta significantly enhanced the anti-tumor effect of 13-cRA. The retinoic acid receptor (RAR)-alpha and RAR-gamma were expressed in RenCa/F cells. Treatment with IFN-alpha/beta did not influence the expression level of these receptors at the mRNA level, which suggests that the synergism of 13-cRA and IFN-alpha/beta is not mediated through the RAR.

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Jul 1998
Volume 13 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Taguchi I, Hara I, Gohji K, Arakawa S and Kamidono S: Synergistic anti-tumor effect of 13-cRA and IFN-alpha/beta in mouse renal cell carcinoma.. Int J Oncol 13: 145-154, 1998
APA
Taguchi, I., Hara, I., Gohji, K., Arakawa, S., & Kamidono, S. (1998). Synergistic anti-tumor effect of 13-cRA and IFN-alpha/beta in mouse renal cell carcinoma.. International Journal of Oncology, 13, 145-154. https://doi.org/10.3892/ijo.13.1.145
MLA
Taguchi, I., Hara, I., Gohji, K., Arakawa, S., Kamidono, S."Synergistic anti-tumor effect of 13-cRA and IFN-alpha/beta in mouse renal cell carcinoma.". International Journal of Oncology 13.1 (1998): 145-154.
Chicago
Taguchi, I., Hara, I., Gohji, K., Arakawa, S., Kamidono, S."Synergistic anti-tumor effect of 13-cRA and IFN-alpha/beta in mouse renal cell carcinoma.". International Journal of Oncology 13, no. 1 (1998): 145-154. https://doi.org/10.3892/ijo.13.1.145