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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Aug 1998 Volume 13 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
Aug 1998 Volume 13 Issue 2

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Article

Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells.

  • Authors:
    • Y H Choi
    • L Zhang
    • W H Lee
    • K Y Park

  • View Affiliations / Copyright

    Affiliations: Medicine Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Pages: 391-397
    |
    Published online on: August 1, 1998
       https://doi.org/10.3892/ijo.13.2.391
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Abstract

Genistein is an isoflavone known to inhibit both tyrosine protein kinase and DNA topoisomerase II. We have investigated the mechanism of genistein-induced growth inhibition in MCF-7 and MDA-MB-231 breast carcinoma cell lines. DNA flow cytometric analysis indicated that genistein induced a G2/M arrest in both cell lines. Therefore, we examined the effect of genistein on cell cycle-related proteins. Western blot analysis using whole cell lysates from MCF-7 and MDA-MB-231 treated with genistein demonstrated that genistein treatment did not change the steady-state level of cdks, cyclin A, D-type cyclins and cyclin E protein, but inhibited expression of cyclin B1 protein in a time-dependent manner. The reduction in the protein level of cyclin B1 correlated with a decrease in the level of cyclin B1 mRNA. Genistein induced expression of p21, and the increased levels of p21 were associated with increased binding of p21 with cdc2 and cdk2. These observations suggest that genistein induces a G2/M arrest in human breast cancer cells, the mechanism of which is in part due to inhibition of kinase activities of cdc2 and cdk2, and decrease in cyclin B1 expression.

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Copy and paste a formatted citation
Spandidos Publications style
Choi Y, Zhang L, Lee W and Park K: Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells.. Int J Oncol 13: 391-397, 1998.
APA
Choi, Y., Zhang, L., Lee, W., & Park, K. (1998). Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells.. International Journal of Oncology, 13, 391-397. https://doi.org/10.3892/ijo.13.2.391
MLA
Choi, Y., Zhang, L., Lee, W., Park, K."Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells.". International Journal of Oncology 13.2 (1998): 391-397.
Chicago
Choi, Y., Zhang, L., Lee, W., Park, K."Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells.". International Journal of Oncology 13, no. 2 (1998): 391-397. https://doi.org/10.3892/ijo.13.2.391
Copy and paste a formatted citation
x
Spandidos Publications style
Choi Y, Zhang L, Lee W and Park K: Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells.. Int J Oncol 13: 391-397, 1998.
APA
Choi, Y., Zhang, L., Lee, W., & Park, K. (1998). Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells.. International Journal of Oncology, 13, 391-397. https://doi.org/10.3892/ijo.13.2.391
MLA
Choi, Y., Zhang, L., Lee, W., Park, K."Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells.". International Journal of Oncology 13.2 (1998): 391-397.
Chicago
Choi, Y., Zhang, L., Lee, W., Park, K."Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells.". International Journal of Oncology 13, no. 2 (1998): 391-397. https://doi.org/10.3892/ijo.13.2.391
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