Allelic loss on chromosome 22 in oral cancer: possibility of the existence of a tumor suppressor gene on 22q13.

  • Authors:
    • A Miyakawa
    • X L Wang
    • H Nakanishi
    • F L Imai
    • M Shiiba
    • T Miya
    • Y Imai
    • H Tanzawa
  • View Affiliations

  • Published online on: October 1, 1998     https://doi.org/10.3892/ijo.13.4.705
  • Pages: 705-714
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Abstract

In order to understand the detail of genetic alternation on chromosome 22, we performed polymerase chain reaction analysis of microsatellite polymorphisms corresponding to 13 loci on chromosome 22. We examined 33 primary carcinoma tissues, 5 metastatic tissues and corresponding normal tissues. We detected microsatellite instability (MI) in 14 (42.4%) of 33 cases in this study. Loss of heterozygosity (LOH) was observed in at least one locus in 24 (72. 7%) of the 33 cases. Among the loci examined, LOH was restricted to D22S274 on chromosome 22q13 in 11 (40.7%) of 27 informative cases. No significant correlation between histological differentiation and LOH was observed. These observations suggest that the incidence of LOH at chromosome 22q is high and is associated with the carcinogenesis of oral squamous cell carcinoma (SCC). The D22S274 locus may play an important role in the development of oral SCC and be the site harboring a putative tumor suppressor gene.

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Oct 1998
Volume 13 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Miyakawa A, Wang X, Nakanishi H, Imai F, Shiiba M, Miya T, Imai Y and Tanzawa H: Allelic loss on chromosome 22 in oral cancer: possibility of the existence of a tumor suppressor gene on 22q13.. Int J Oncol 13: 705-714, 1998
APA
Miyakawa, A., Wang, X., Nakanishi, H., Imai, F., Shiiba, M., Miya, T. ... Tanzawa, H. (1998). Allelic loss on chromosome 22 in oral cancer: possibility of the existence of a tumor suppressor gene on 22q13.. International Journal of Oncology, 13, 705-714. https://doi.org/10.3892/ijo.13.4.705
MLA
Miyakawa, A., Wang, X., Nakanishi, H., Imai, F., Shiiba, M., Miya, T., Imai, Y., Tanzawa, H."Allelic loss on chromosome 22 in oral cancer: possibility of the existence of a tumor suppressor gene on 22q13.". International Journal of Oncology 13.4 (1998): 705-714.
Chicago
Miyakawa, A., Wang, X., Nakanishi, H., Imai, F., Shiiba, M., Miya, T., Imai, Y., Tanzawa, H."Allelic loss on chromosome 22 in oral cancer: possibility of the existence of a tumor suppressor gene on 22q13.". International Journal of Oncology 13, no. 4 (1998): 705-714. https://doi.org/10.3892/ijo.13.4.705