Evaluation of radiation effects against C6 glioma in combination with vaccinia virus-p53 gene therapy.

  • Authors:
    • D S Gridley
    • M L Andres
    • J Li
    • T Timiryasova
    • B Chen
    • I Fodor
  • View Affiliations

  • Published online on: November 1, 1998     https://doi.org/10.3892/ijo.13.5.1093
  • Pages: 1093-1101
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Abstract

The primary objective of this study was to evaluate the antitumor effects of recombinant vaccinia virus-p53 (rVV-p53) in combination with radiation therapy against the C6 rat glioma, a p53 deficient tumor that is relatively radioresistant. VV-LIVP, the parental virus (Lister strain), was used as a control. Localized treatment of subcutaneous C6 tumors in athymic mice with either rVV-p53 or VV-LIVP together with tumor irradiation resulted in low tumor incidence and significantly slower tumor progression compared to the agents given as single modalities. Assays of blood and spleen indicated that immune system activation may account, at least partly, for the enhance tumor inhibition seen with combined treatment. No overt signs of treatment-related toxicity were noted.

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Nov 1998
Volume 13 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Gridley D, Andres M, Li J, Timiryasova T, Chen B and Fodor I: Evaluation of radiation effects against C6 glioma in combination with vaccinia virus-p53 gene therapy.. Int J Oncol 13: 1093-1101, 1998.
APA
Gridley, D., Andres, M., Li, J., Timiryasova, T., Chen, B., & Fodor, I. (1998). Evaluation of radiation effects against C6 glioma in combination with vaccinia virus-p53 gene therapy.. International Journal of Oncology, 13, 1093-1101. https://doi.org/10.3892/ijo.13.5.1093
MLA
Gridley, D., Andres, M., Li, J., Timiryasova, T., Chen, B., Fodor, I."Evaluation of radiation effects against C6 glioma in combination with vaccinia virus-p53 gene therapy.". International Journal of Oncology 13.5 (1998): 1093-1101.
Chicago
Gridley, D., Andres, M., Li, J., Timiryasova, T., Chen, B., Fodor, I."Evaluation of radiation effects against C6 glioma in combination with vaccinia virus-p53 gene therapy.". International Journal of Oncology 13, no. 5 (1998): 1093-1101. https://doi.org/10.3892/ijo.13.5.1093