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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Dec 1998 Volume 13 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Dec 1998 Volume 13 Issue 6

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Article

Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.

  • Authors:
    • J Schlegel
    • K Muenkel
    • T Trenkle
    • G Fauser
    • J Ruschoff
  • View Affiliations / Copyright

    Affiliations: Department of Neuropathology, University Medical Center, D-35043 Marburg, Germany.
  • Pages: 1281-1285
    |
    Published online on: December 1, 1998
       https://doi.org/10.3892/ijo.13.6.1281
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Abstract

In the present study we investigated the expression of the ERBB2 protein and neurofibromin in human benign and malignant Schwann cell tumors, traumatic neuromas and peripheral nerves without pathological findings. By immunohistochemistry and Western analysis ERBB2 expression was not detectable in normal nerves but in proliferating Schwann cells of traumatic neuromas. While none of the malignant schwannomas exhibited ERBB2 expression, weak expression was seen in a small proportion of the benign schwannomas. Low levels of neurofibromin were detectable in normal nerves but not in traumatic neuromas or tumors. These data indicate an inverse expression pattern of ERBB2 and neurofibromin in human non-neoplastic Schwann cells, but not in neurinoma cells.

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Copy and paste a formatted citation
Spandidos Publications style
Schlegel J, Muenkel K, Trenkle T, Fauser G and Ruschoff J: Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.. Int J Oncol 13: 1281-1285, 1998.
APA
Schlegel, J., Muenkel, K., Trenkle, T., Fauser, G., & Ruschoff, J. (1998). Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.. International Journal of Oncology, 13, 1281-1285. https://doi.org/10.3892/ijo.13.6.1281
MLA
Schlegel, J., Muenkel, K., Trenkle, T., Fauser, G., Ruschoff, J."Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.". International Journal of Oncology 13.6 (1998): 1281-1285.
Chicago
Schlegel, J., Muenkel, K., Trenkle, T., Fauser, G., Ruschoff, J."Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.". International Journal of Oncology 13, no. 6 (1998): 1281-1285. https://doi.org/10.3892/ijo.13.6.1281
Copy and paste a formatted citation
x
Spandidos Publications style
Schlegel J, Muenkel K, Trenkle T, Fauser G and Ruschoff J: Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.. Int J Oncol 13: 1281-1285, 1998.
APA
Schlegel, J., Muenkel, K., Trenkle, T., Fauser, G., & Ruschoff, J. (1998). Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.. International Journal of Oncology, 13, 1281-1285. https://doi.org/10.3892/ijo.13.6.1281
MLA
Schlegel, J., Muenkel, K., Trenkle, T., Fauser, G., Ruschoff, J."Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.". International Journal of Oncology 13.6 (1998): 1281-1285.
Chicago
Schlegel, J., Muenkel, K., Trenkle, T., Fauser, G., Ruschoff, J."Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.". International Journal of Oncology 13, no. 6 (1998): 1281-1285. https://doi.org/10.3892/ijo.13.6.1281
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