Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.

  • Authors:
    • J Schlegel
    • K Muenkel
    • T Trenkle
    • G Fauser
    • J Ruschoff
  • View Affiliations

  • Published online on: December 1, 1998     https://doi.org/10.3892/ijo.13.6.1281
  • Pages: 1281-1285
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Abstract

In the present study we investigated the expression of the ERBB2 protein and neurofibromin in human benign and malignant Schwann cell tumors, traumatic neuromas and peripheral nerves without pathological findings. By immunohistochemistry and Western analysis ERBB2 expression was not detectable in normal nerves but in proliferating Schwann cells of traumatic neuromas. While none of the malignant schwannomas exhibited ERBB2 expression, weak expression was seen in a small proportion of the benign schwannomas. Low levels of neurofibromin were detectable in normal nerves but not in traumatic neuromas or tumors. These data indicate an inverse expression pattern of ERBB2 and neurofibromin in human non-neoplastic Schwann cells, but not in neurinoma cells.

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Dec 1998
Volume 13 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Schlegel J, Muenkel K, Trenkle T, Fauser G and Ruschoff J: Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.. Int J Oncol 13: 1281-1285, 1998
APA
Schlegel, J., Muenkel, K., Trenkle, T., Fauser, G., & Ruschoff, J. (1998). Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.. International Journal of Oncology, 13, 1281-1285. https://doi.org/10.3892/ijo.13.6.1281
MLA
Schlegel, J., Muenkel, K., Trenkle, T., Fauser, G., Ruschoff, J."Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.". International Journal of Oncology 13.6 (1998): 1281-1285.
Chicago
Schlegel, J., Muenkel, K., Trenkle, T., Fauser, G., Ruschoff, J."Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.". International Journal of Oncology 13, no. 6 (1998): 1281-1285. https://doi.org/10.3892/ijo.13.6.1281