Close correlation between a p53 or hMSH2 gene mutation in the tumor and survival of hepatocellular carcinoma patients.

  • Authors:
    • M Yano
    • T Asahara
    • K Dohi
    • T Mizuno
    • K S Iwamoto
    • T Seyama
  • View Affiliations

  • Published online on: March 1, 1999     https://doi.org/10.3892/ijo.14.3.447
  • Pages: 447-498
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Abstract

We analyzed 42 hepatocellular carcinomas (HCC) (38 patients) for mutations in the DNA mismatch repair gene hMSH2 and the p53 tumor suppressor gene, a possible upregulater of hMSH2. Mutations of the hMSH2 or p53 gene were detected in 13 patients (34%). There were no patients who possessed mutations in both genes. There was a significant correlation between mutation of either gene and pathological indicators of malignancy. The survival rate of patients with hMSH2 or p53 gene mutation-positive tumors was much poorer than that with hMSH2 and p53 gene mutation-negative tumors (p=0.0012). Our results suggest that mutations in the p53 or hMSH2 gene may closely correlate with the survival of hepatocellular carcinoma patients.

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Mar 1999
Volume 14 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Yano M, Asahara T, Dohi K, Mizuno T, Iwamoto K and Seyama T: Close correlation between a p53 or hMSH2 gene mutation in the tumor and survival of hepatocellular carcinoma patients.. Int J Oncol 14: 447-498, 1999
APA
Yano, M., Asahara, T., Dohi, K., Mizuno, T., Iwamoto, K., & Seyama, T. (1999). Close correlation between a p53 or hMSH2 gene mutation in the tumor and survival of hepatocellular carcinoma patients.. International Journal of Oncology, 14, 447-498. https://doi.org/10.3892/ijo.14.3.447
MLA
Yano, M., Asahara, T., Dohi, K., Mizuno, T., Iwamoto, K., Seyama, T."Close correlation between a p53 or hMSH2 gene mutation in the tumor and survival of hepatocellular carcinoma patients.". International Journal of Oncology 14.3 (1999): 447-498.
Chicago
Yano, M., Asahara, T., Dohi, K., Mizuno, T., Iwamoto, K., Seyama, T."Close correlation between a p53 or hMSH2 gene mutation in the tumor and survival of hepatocellular carcinoma patients.". International Journal of Oncology 14, no. 3 (1999): 447-498. https://doi.org/10.3892/ijo.14.3.447