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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Mar 1999 Volume 14 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Mar 1999 Volume 14 Issue 3

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Article

Loss of two new loci on chromosome 8 (8p23 and 8q12-13) in human prostate cancer.

  • Authors:
    • G Perinchery
    • N Bukurov
    • K Nakajima
    • J Chang
    • M Hooda
    • B R Oh
    • R Dahiya

  • View Affiliations / Copyright

    Affiliations: Department of Urology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
  • Pages: 495-995
    |
    Published online on: March 1, 1999
       https://doi.org/10.3892/ijo.14.3.495
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Abstract

Inactivation of tumor suppressor genes due to allelic loss is thought to be an important mechanism of gene alterations in prostatic carcinogenesis. Loss of sequences on the short arm of chromosome 8 (8p) has been reported in human cancers, especially of 8p22 and 8p12-21 in prostate cancer. By using PCR analysis of polymorphic microsatellite repeat markers at four 8p loci and three 8q loci in 60 tumors, we observed deletion of sequences at two other deletion domains (8p23, and 8q12-13). There was loss in 51 of 60 cases (85%) with at least one marker. Four distinct regions of loss detected were: i) at 8p23, at locus D8S262; ii) at 8p22, on locus D8S259; iii) at 8p12, on loci D8S255 and D8S285; iv) at 8q12-13, on loci between D8S260 and D8S528. We found that 29% of the tumors showed LOH at 8p23; 19% LOH on 8p22; 54% had LOH at 8p12; and 48% had LOH at 8q12-13. There was higher frequency of LOH at 3 or more loci in samples of T3 stage (62%) as compared to T2 stage (13.3%) which suggests higher incidence of LOH in advanced stage of prostate cancer. We report deletion of two novel loci at 8p23 and 8q12-13, these regions may contain putative tumor suppressor genes in prostate cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Perinchery G, Bukurov N, Nakajima K, Chang J, Hooda M, Oh B and Dahiya R: Loss of two new loci on chromosome 8 (8p23 and 8q12-13) in human prostate cancer.. Int J Oncol 14: 495-995, 1999.
APA
Perinchery, G., Bukurov, N., Nakajima, K., Chang, J., Hooda, M., Oh, B., & Dahiya, R. (1999). Loss of two new loci on chromosome 8 (8p23 and 8q12-13) in human prostate cancer.. International Journal of Oncology, 14, 495-995. https://doi.org/10.3892/ijo.14.3.495
MLA
Perinchery, G., Bukurov, N., Nakajima, K., Chang, J., Hooda, M., Oh, B., Dahiya, R."Loss of two new loci on chromosome 8 (8p23 and 8q12-13) in human prostate cancer.". International Journal of Oncology 14.3 (1999): 495-995.
Chicago
Perinchery, G., Bukurov, N., Nakajima, K., Chang, J., Hooda, M., Oh, B., Dahiya, R."Loss of two new loci on chromosome 8 (8p23 and 8q12-13) in human prostate cancer.". International Journal of Oncology 14, no. 3 (1999): 495-995. https://doi.org/10.3892/ijo.14.3.495
Copy and paste a formatted citation
x
Spandidos Publications style
Perinchery G, Bukurov N, Nakajima K, Chang J, Hooda M, Oh B and Dahiya R: Loss of two new loci on chromosome 8 (8p23 and 8q12-13) in human prostate cancer.. Int J Oncol 14: 495-995, 1999.
APA
Perinchery, G., Bukurov, N., Nakajima, K., Chang, J., Hooda, M., Oh, B., & Dahiya, R. (1999). Loss of two new loci on chromosome 8 (8p23 and 8q12-13) in human prostate cancer.. International Journal of Oncology, 14, 495-995. https://doi.org/10.3892/ijo.14.3.495
MLA
Perinchery, G., Bukurov, N., Nakajima, K., Chang, J., Hooda, M., Oh, B., Dahiya, R."Loss of two new loci on chromosome 8 (8p23 and 8q12-13) in human prostate cancer.". International Journal of Oncology 14.3 (1999): 495-995.
Chicago
Perinchery, G., Bukurov, N., Nakajima, K., Chang, J., Hooda, M., Oh, B., Dahiya, R."Loss of two new loci on chromosome 8 (8p23 and 8q12-13) in human prostate cancer.". International Journal of Oncology 14, no. 3 (1999): 495-995. https://doi.org/10.3892/ijo.14.3.495
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