Apoptotic cell death of human gastric tumor induced by nucleosides from CD57+HLA-DRbright natural suppressor cell line.

  • Authors:
    • X Li
    • J Xu
    • M Guo
    • E Mori
    • T Mori
  • View Affiliations

  • Published online on: April 1, 1999     https://doi.org/10.3892/ijo.14.4.687
  • Pages: 687-781
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

CD57+HLA-DRbright natural suppressor (57.DR-NS) cell line derived from human decidual tissue generated apoptosis in a human gastric carcinoma cell line (GCIY) but not in a human diploid normal cell line (WI-38). The factors released from 57.DR-NS cells were purified by thin-layer-chromatography (TLC) and separated by high performance liquid chromatography (HPLC) into six components. The physicochemical structures of the six components were determined as a series of nucleosides and their modified forms collectively termed in a previous study. They could generate apoptotic cell death of GCIY malignant target cells, but not disturb the viability of WI-38 normal target cells. The administration of AINs into GCIY tumor bearing SCID mice resulted in drastic suppression of tumor growth followed by the decrease in tumor size due to the occurrence of apoptosis in tumor tissues.

Related Articles

Journal Cover

Apr 1999
Volume 14 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Xu J, Guo M, Mori E and Mori T: Apoptotic cell death of human gastric tumor induced by nucleosides from CD57+HLA-DRbright natural suppressor cell line.. Int J Oncol 14: 687-781, 1999
APA
Li, X., Xu, J., Guo, M., Mori, E., & Mori, T. (1999). Apoptotic cell death of human gastric tumor induced by nucleosides from CD57+HLA-DRbright natural suppressor cell line.. International Journal of Oncology, 14, 687-781. https://doi.org/10.3892/ijo.14.4.687
MLA
Li, X., Xu, J., Guo, M., Mori, E., Mori, T."Apoptotic cell death of human gastric tumor induced by nucleosides from CD57+HLA-DRbright natural suppressor cell line.". International Journal of Oncology 14.4 (1999): 687-781.
Chicago
Li, X., Xu, J., Guo, M., Mori, E., Mori, T."Apoptotic cell death of human gastric tumor induced by nucleosides from CD57+HLA-DRbright natural suppressor cell line.". International Journal of Oncology 14, no. 4 (1999): 687-781. https://doi.org/10.3892/ijo.14.4.687