Hyaluronan activates mitogen-activated protein kinase via Ras-signaling pathway.

Serbulea,M; Kakumu,S; Thant,A A; Miyazaki,K; Machida,K; Senga,T; Ohta,S; Yoshioka,K; Hotta,N; Hamaguchi,M

doi:10.3892/ijo.14.4.733

Apr 1999 Volume 14 Issue 4

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Apr 1999 Volume 14 Issue 4

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Article

Hyaluronan activates mitogen-activated protein kinase via Ras-signaling pathway.

Authors:
- M Serbulea
- S Kakumu
- A A Thant
- K Miyazaki
- K Machida
- T Senga
- S Ohta
- K Yoshioka
- N Hotta
- M Hamaguchi
View Affiliations / Copyright

Affiliations: Departments of Internal Medicine III and Molecular Pathogenesis, Nagoya University School of Medicine, Showa-ku, Nagoya 466-8550, Japan.
Pages: 733-741
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Published online on: April 1, 1999

https://doi.org/10.3892/ijo.14.4.733
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Abstract

Hyaluronan (HA) triggers a wide variety of cellular functions, yet its signaling pathway remains largely unclear. We found that HA-treatment of 3Y1 cells activated tyrosine phosphorylation of cellular proteins and mitogen-activated protein (MAP) kinase in a time- and dose-dependent manner, and, subsequently, stimulated cell growth. This HA-activity was resistant to boiling at 100 degrees C but completely abolished by treatment with hyaluronidase, suggesting that HA itself, but not any HA-associated proteins, has the activity. In addition, we found that HA-dependent activation of MAP kinase was strongly suppressed by the expression of dominant negative ras (S17N ras). These results suggest that Ras-MAP kinase pathway is activated by HA and may play an important role in HA-dependent signaling.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Hyaluronan activates mitogen-activated protein kinase via Ras-signaling pathway.

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