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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 1999 Volume 14 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1999 Volume 14 Issue 5

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Article

GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin.

  • Authors:
    • K Zhang
    • E B Yang
    • K P Wong
    • P Mack

  • View Affiliations / Copyright

    Affiliations: Department of Experimental Surgery, BLK 9, Level 2, Singapore General Hospital, Singapore 169608, Singapore.
  • Pages: 861-868
    |
    Published online on: May 1, 1999
       https://doi.org/10.3892/ijo.14.5.861
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Abstract

Glutathione (GSH) contents and activities of glutathione S-transferase (GST), glutathione reductase (GSH-RD), glutathione peroxidase (GSHpx) and glutathione conjugate export pump (GS-X pump) were determined in eight human tumor cell lines with different sensitivities to adriamycin and chlorambucil. Correlations between sensitivities of the human tumor cells to adriamycin and chlorambucil and the glutathione related factors were analyzed statistically. Sensitivities of the human tumor cells to chlorambucil were found to be correlated to all the glutathione related factors tested (r=0.68-0.88). IC50 values of adriamycin were also positively correlated to GSH contents and activities of GSH-RD, GSHpx and GS-X pump with r values ranging from 0.66 to 0.77 but not to GST activity (r=0.25). Chang liver cells with highest GSH content and highest activities of GST, GSH-RD, GSHpx and GS-X pump were most resistant to both adriamycin and chlorambucil. These data suggested that glutathione related factors may work as an overall detoxification system participating in the detoxification of anticancer drugs such as adriamycin and chlorambucil, and to be involved in cellular resistance to these drugs.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang K, Yang E, Wong K and Mack P: GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin.. Int J Oncol 14: 861-868, 1999.
APA
Zhang, K., Yang, E., Wong, K., & Mack, P. (1999). GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin.. International Journal of Oncology, 14, 861-868. https://doi.org/10.3892/ijo.14.5.861
MLA
Zhang, K., Yang, E., Wong, K., Mack, P."GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin.". International Journal of Oncology 14.5 (1999): 861-868.
Chicago
Zhang, K., Yang, E., Wong, K., Mack, P."GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin.". International Journal of Oncology 14, no. 5 (1999): 861-868. https://doi.org/10.3892/ijo.14.5.861
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang K, Yang E, Wong K and Mack P: GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin.. Int J Oncol 14: 861-868, 1999.
APA
Zhang, K., Yang, E., Wong, K., & Mack, P. (1999). GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin.. International Journal of Oncology, 14, 861-868. https://doi.org/10.3892/ijo.14.5.861
MLA
Zhang, K., Yang, E., Wong, K., Mack, P."GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin.". International Journal of Oncology 14.5 (1999): 861-868.
Chicago
Zhang, K., Yang, E., Wong, K., Mack, P."GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin.". International Journal of Oncology 14, no. 5 (1999): 861-868. https://doi.org/10.3892/ijo.14.5.861
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