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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Jul 1999 Volume 15 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jul 1999 Volume 15 Issue 1

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Article

Suppression of tumorigenicity in cervical carcinoma HeLa cells by an episomal form of adeno-associated virus.

  • Authors:
    • F Y Wu
    • C Y Wu
    • C H Lin
    • C H Wu

  • View Affiliations / Copyright

    Affiliations: Division of Cancer Research, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan, R.O.C.
  • Pages: 101-107
    |
    Published online on: July 1, 1999
       https://doi.org/10.3892/ijo.15.1.101
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Abstract

To compare the oncosuppressive activity of integrated and episomal adeno-associated virus (AAV), two Epstein-Barr virus (EBV) derived episomal form vectors, p205 and p220, were used to generate plasmids containing episomal AAV. HeLa cells transfected with p205, p220, and the plasmids with forward (pA205-1, pA220-1) and reverse (pA205-1, pA220-2) orientation of inserted AAV DNA were designated H205, H220, HA205-1, HA220-1, HA205-1, and Ha220-2, respectively. The respective average copy numbers of pA205 and pA220 per cell are 4.9-6.9 and 4.3. The AAV-transfected HeLa cells displayed growth inhibition when compared to parental and the vector-transfected HeLa cells. Nude mice assay showed that the tumor size from HA205-1 and HA205-2 cells were 11.3 and 22.6%, and those from HA220-1 and HA220-2 cells were 54.8 and 57.3%, respectively, when compared to parental HeLa cells. HA205-1 cells containing forward AAV insert exerted more oncosuppressive effect than HA205-2 cells containing reverse AAV insert. Our data indicate that the episomal AAV can exert oncosuppressive activity as compared to the integrated AAV in HeLa cells.

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Copy and paste a formatted citation
Spandidos Publications style
Wu F, Wu C, Lin C and Wu C: Suppression of tumorigenicity in cervical carcinoma HeLa cells by an episomal form of adeno-associated virus.. Int J Oncol 15: 101-107, 1999.
APA
Wu, F., Wu, C., Lin, C., & Wu, C. (1999). Suppression of tumorigenicity in cervical carcinoma HeLa cells by an episomal form of adeno-associated virus.. International Journal of Oncology, 15, 101-107. https://doi.org/10.3892/ijo.15.1.101
MLA
Wu, F., Wu, C., Lin, C., Wu, C."Suppression of tumorigenicity in cervical carcinoma HeLa cells by an episomal form of adeno-associated virus.". International Journal of Oncology 15.1 (1999): 101-107.
Chicago
Wu, F., Wu, C., Lin, C., Wu, C."Suppression of tumorigenicity in cervical carcinoma HeLa cells by an episomal form of adeno-associated virus.". International Journal of Oncology 15, no. 1 (1999): 101-107. https://doi.org/10.3892/ijo.15.1.101
Copy and paste a formatted citation
x
Spandidos Publications style
Wu F, Wu C, Lin C and Wu C: Suppression of tumorigenicity in cervical carcinoma HeLa cells by an episomal form of adeno-associated virus.. Int J Oncol 15: 101-107, 1999.
APA
Wu, F., Wu, C., Lin, C., & Wu, C. (1999). Suppression of tumorigenicity in cervical carcinoma HeLa cells by an episomal form of adeno-associated virus.. International Journal of Oncology, 15, 101-107. https://doi.org/10.3892/ijo.15.1.101
MLA
Wu, F., Wu, C., Lin, C., Wu, C."Suppression of tumorigenicity in cervical carcinoma HeLa cells by an episomal form of adeno-associated virus.". International Journal of Oncology 15.1 (1999): 101-107.
Chicago
Wu, F., Wu, C., Lin, C., Wu, C."Suppression of tumorigenicity in cervical carcinoma HeLa cells by an episomal form of adeno-associated virus.". International Journal of Oncology 15, no. 1 (1999): 101-107. https://doi.org/10.3892/ijo.15.1.101
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