Elevated blood levels of soluble tumor necrosis factor receptors in nasopharyngeal carcinoma: correlation with humoral immune response to lytic replication of Epstein-Barr virus.

  • Authors:
    • P Feng
    • S H Chan
    • E E Ooi
    • M Y Soo
    • K S Loh
    • D Wang
    • E C Ren
    • H Hu
  • View Affiliations

  • Published online on: July 1, 1999     https://doi.org/10.3892/ijo.15.1.167
  • Pages: 167-239
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Abstract

Nasopharyngeal carcinoma (NPC) is tightly associated with Epstein-Barr virus (EBV) infection and a heavy infiltration of lymphoid cells in the tumor tissue. Although various lines of evidence have shown that the immune systems of NPC patients have the potential to attack the tumor cells, it is not yet understood how this potential is blocked. In this study we determined the circulatory soluble tumor necrosis factor receptors (sTNFRI and sTNFRII), which are proven to be inhibitory to the anti-tumor effects of tumor necrosis factor-alpha (TNF-alpha), in NPC patients. The serum concentration of both sTNFRI and sTNFRII was determined with an ELISA method, and shown to be significantly higher in 28 NPC patients than in matched healthy controls. This elevation was found to be positively correlated with the serum titers of IgA against EBV early antigens and viral capsid antigens in NPC patients, suggesting that the increased serum concentration of sTNFRI and sTNFRII is possibly due to the EBV infection in NPC tumor cells. This is partly supported by FACS analysis of the circulatory T cells. Phenotypical expression of activation markers such as CD25, CD38, CD69 and CD71 in blood T cells was not significantly different between the NPC and control individuals, indicating the elevation of the sTNFRs is indeed derived from the local immune response in the tumor area. Based on these results, it seems that the increased sTNFRs may act as an inhibitor to decrease the host immune response towards tumor cells in NPC patients.

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Jul 1999
Volume 15 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Feng P, Chan S, Ooi E, Soo M, Loh K, Wang D, Ren E and Hu H: Elevated blood levels of soluble tumor necrosis factor receptors in nasopharyngeal carcinoma: correlation with humoral immune response to lytic replication of Epstein-Barr virus.. Int J Oncol 15: 167-239, 1999
APA
Feng, P., Chan, S., Ooi, E., Soo, M., Loh, K., Wang, D. ... Hu, H. (1999). Elevated blood levels of soluble tumor necrosis factor receptors in nasopharyngeal carcinoma: correlation with humoral immune response to lytic replication of Epstein-Barr virus.. International Journal of Oncology, 15, 167-239. https://doi.org/10.3892/ijo.15.1.167
MLA
Feng, P., Chan, S., Ooi, E., Soo, M., Loh, K., Wang, D., Ren, E., Hu, H."Elevated blood levels of soluble tumor necrosis factor receptors in nasopharyngeal carcinoma: correlation with humoral immune response to lytic replication of Epstein-Barr virus.". International Journal of Oncology 15.1 (1999): 167-239.
Chicago
Feng, P., Chan, S., Ooi, E., Soo, M., Loh, K., Wang, D., Ren, E., Hu, H."Elevated blood levels of soluble tumor necrosis factor receptors in nasopharyngeal carcinoma: correlation with humoral immune response to lytic replication of Epstein-Barr virus.". International Journal of Oncology 15, no. 1 (1999): 167-239. https://doi.org/10.3892/ijo.15.1.167