Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.

  • Authors:
    • J Edwards
    • J M Bartlett
  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/ijo.15.3.583
  • Pages: 583-591
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Inhibition of mitosis or induction of apoptosis are pathways at which anti tumour therapies could be aimed. This study evaluates the actions of CGP52411 (cell growth inhibitor) and transforming growth factor beta1 (TGFbeta1) (inducer of apoptosis) alone and in combination on two ovarian carcinoma cell lines (PEO1 and OVCAR3). In both cell lines TGFbeta1 treatment increased the level of apoptotic cells and CGP52411 treatment reduced EGF stimulated cell growth. Combined treatment further reduced cell numbers in PEO1 cultures, demonstrating that dual therapy aimed at both aspects of cell regulation has a greater anti tumour action.

Related Articles

Journal Cover

Sep 1999
Volume 15 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Edwards J and Edwards J: Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.. Int J Oncol 15: 583-591, 1999
APA
Edwards, J., & Edwards, J. (1999). Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.. International Journal of Oncology, 15, 583-591. https://doi.org/10.3892/ijo.15.3.583
MLA
Edwards, J., Bartlett, J."Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.". International Journal of Oncology 15.3 (1999): 583-591.
Chicago
Edwards, J., Bartlett, J."Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.". International Journal of Oncology 15, no. 3 (1999): 583-591. https://doi.org/10.3892/ijo.15.3.583